ArticlePloS one2013
Dab2IP GTPase activating protein regulates dendrite development and synapse number in cerebellum.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- DAB2IP: unifying cardiovascular pathogenesis and cardiovascular brain crosstalk.Frontiers in cardiovascular medicine · 2026Review
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- Differential Expression of Proteins Associated with Bipolar Disorder as Identified Using the PeptideShaker Software.International journal of molecular sciences · 2023Article
- Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma.Cell death & disease · 2020Article
- Pumping the brakes on RAS - negative regulators and death effectors of RAS.Journal of cell science · 2020Review
- Current Opinions and Consensus for Studying Tremor in Animal Models.Cerebellum (London, England) · 2019Review
- Disabled homolog 2 interactive protein functions as a tumor suppressor in osteosarcoma cells.Oncology letters · 2018Article
- Protein kinase N1 critically regulates cerebellar development and long-term function.The Journal of clinical investigation · 2018Article
- Relatively frequent switching of transcription start sites during cerebellar development.BMC genomics · 2017Article
- Alterations of Cell Proliferation and Apoptosis in the Hypoplastic Reeler Cerebellum.Frontiers in cellular neuroscience · 2016Article
- New Insights into Reelin-Mediated Signaling Pathways.Frontiers in cellular neuroscience · 2016Review
- Expression of mouse Dab2ip transcript variants and gene methylation during brain development.Gene · 2015Article
- Article
- Dab2IP Regulates Neuronal Positioning, Rap1 Activity and Integrin Signaling in the Developing Cortex.Developmental neuroscience · 2015Article
- Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum.Brain : a journal of neurology · 2014Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
DOC-2/DAB-2 interacting protein (Dab2IP) is a GTPase activating protein that binds to Disabled-1, a cytosolic adapter protein involved in Reelin signaling and brain development. Dab2IP regulates PI3K-AKT signaling and is associated with metastatic prostate cancer, abdominal aortic aneurysms and coronary heart disease. To date, the physiological function of Dab2IP in the nervous system, where it is highly expressed, is relatively unknown. In this study, we generated a mouse model with a targeted disruption of Dab2IP using a retrovirus gene trap strategy. Unlike reeler mice, Dab2IP knock-down mice did not exhibit severe ataxia or cerebellar hypoplasia. However, Dab2IP deficiency produced a number of cerebellar abnormalities such as a delay in the development of Purkinje cell (PC) dendrites, a decrease in the parallel fiber synaptic marker VGluT1, and an increase in the climbing fiber synaptic marker VGluT2. These findings demonstrate for the first time that Dab2IP plays an important role in dendrite development and regulates the number of synapses in the cerebellum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.