ArticlePloS one2013
Is the interplay between epigenetic markers related to the acclimation of cork oak plants to high temperatures?
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 94 citations in OpenAlex.
- Short-Term Epigenetic Responses ofGenes · 2026Article
- Epigenetic Mechanisms Driving Adaptation in Tropical and Subtropical Plants: Insights and Future Directions.Plant, cell & environment · 2025Review
- A chromosome-scale genome assembly and epigenomic profiling reveal temperature-dependent histone methylation in iridoid biosynthesis regulation inHorticulture research · 2025Article
- Epigenetic responses of trees to environmental stress in the context of climate change.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Response of Pedunculate Oak (Plants (Basel, Switzerland) · 2025Review
- Cotton under heat stress: a comprehensive review of molecular breeding, genomics, and multi-omics strategies.Frontiers in genetics · 2025Review
- Response Mechanisms of Woody Plants to High-Temperature Stress.Plants (Basel, Switzerland) · 2023Review
- Cork Development: What Lies Within.Plants (Basel, Switzerland) · 2022Review
- Multiomics Molecular Research into the Recalcitrant and OrphanInternational journal of molecular sciences · 2022Review
- Diverging responses of water and carbon relations during and after heat and hot drought stress in Pinus sylvestris.Tree physiology · 2022Article
- DNA methylation and histone modifications induced by abiotic stressors in plants.Genes & genomics · 2022Review
- The role of maternal age, growth, and environment in shaping offspring performance in an aerial conifer seed bank.American journal of botany · 2022Article
- Role of Epigenetics in Modulating Phenotypic Plasticity against Abiotic Stresses in Plants.International journal of genomics · 2022Review
- Can Forest Trees Cope with Climate Change?-Effects of DNA Methylation on Gene Expression and Adaptation to Environmental Change.International journal of molecular sciences · 2021Review
- Heat Stress inPlants (Basel, Switzerland) · 2021Article
- Review
- Article
- Integrated Transcriptome Analysis and Single-Base Resolution Methylomes of Watermelon (Frontiers in plant science · 2021Article
- Plant Responses to Heat Stress: Physiology, Transcription, Noncoding RNAs, and Epigenetics.International journal of molecular sciences · 2020Review
- Epigenetic memory and priming in plants.Genetica · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trees necessarily experience changes in temperature, requiring efficient short-term strategies that become crucial in environmental change adaptability. DNA methylation and histone posttranslational modifications have been shown to play a key role in both epigenetic control and plant functional status under stress by controlling the functional state of chromatin and gene expression. Cork oak (Quercus suber L.) is a key stone of the Mediterranean region, growing at temperatures of 45°C. This species was subjected to a cumulative temperature increase from 25°C to 55°C under laboratory conditions in order to test the hypothesis that epigenetic code is related to heat stress tolerance. Electrolyte leakage increased after 35°C, but all plants survived to 55°C. DNA methylation and acetylated histone H3 (AcH3) levels were monitored by HPCE (high performance capillary electrophoresis), MS-RAPD (methylation-sensitive random-amplified polymorphic DNA) and Protein Gel Blot analysis and the spatial distribution of the modifications was assessed using a confocal microscope. DNA methylation analysed by HPCE revealed an increase at 55°C, while MS-RAPD results pointed to dynamic methylation-demethylation patterns over stress. Protein Gel Blot showed the abundance index of AcH3 decreasing from 25°C to 45°C. The immunohistochemical detection of 5-mC (5-methyl-2'-deoxycytidine) and AcH3 came upon the previous results. These results indicate that epigenetic mechanisms such as DNA methylation and histone H3 acetylation have opposite and particular dynamics that can be crucial for the stepwise establishment of this species into such high stress (55°C), allowing its acclimation and survival. This is the first report that assesses epigenetic regulation in order to investigate heat tolerance in forest trees.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.