Evidence map›Paper›PMID 23326436›Full record

ArticlePloS one2013

Multidrug and extensively drug-resistant tuberculosis in Canada 1997-2008: demographic and disease characteristics.

Jessica Minion, Victor Gallant, Joyce Wolfe, Frances Jamieson, Richard Long

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 5 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  11. Risk factors for drug-resistant tuberculosis at a referral centre in Toronto, Ontario, Canada: 2010-2016.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2020
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  19. A 39-year-old female immigrant with chronic diarrhea.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Jessica MinionDepartment of Medical Microbiology & Immunology, University of Alberta, Edmonton, Canada.
Victor Gallant
Joyce Wolfe
Frances Jamieson
Richard Long
University of Alberta · CACanadian Science Centre for Human and Animal Health · CAPublic Health Agency of Canada · CAToronto Public Health · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

settingNationwide Canadian public health surveillance.

objectiveDescription of demographic features and disease characteristics of drug-resistant tuberculosis (TB) in Canada over a 12 year period.

designContinuous surveillance of all cases of culture-confirmed TB in Canada. Demographic and microbiologic features were analyzed and comparisons between drug-susceptible, multidrug-resistant (MDR), and drug-resistant not-MDR were made. Cases of extensively drug resistant TB are described.

results15,993 cases of culture-confirmed TB were reported during the study period. There were 5 cases of XDR-TB, 177 cases of MDR-TB, and 1,234 cases of first-line drug resistance not-MDR. The majority of drug-resistant cases were reported in foreign-born individuals, with drug-resistant cases diagnosed earlier post-arrival in Canada compared to drug-susceptible cases. In MDR-TB isolates, there was a high rate of drug-resistance to other first- and second-line drugs, making reliable empiric therapeutic recommendations for MDR-TB difficult. There was a statistically significant association between both MDR and drug-resistance not-MDR, and the risk of a negative treatment outcome (defined as treatment failure, absconded, or treatment ongoing >3 yrs).

conclusionDrug-resistance complicates TB management even in developed nations with well-established TB control programs. The predominantly international origin of drug-resistant cases highlights the need for global strategies to combat TB.

Indexed as

AdolescentAdultAntitubercular AgentsCanadaChildChild, PreschoolDemographyExtensively Drug-Resistant TuberculosisFemaleHumansIncidenceInfantInfant, NewbornMaleMiddle AgedMycobacterium tuberculosisAntitubercular Agents

Identifiers

PMID23326436
PMCPMC3541271
OpenAlexW1987806720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.