ArticlePloS one2013
Rescue of inhibitory synapse strength following developmental hearing loss.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Biosafety and efficacy of Kv7 activating rdHSV-CA8∗ analgesic gene therapy for chronic pain via the intra-articular route in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Formation of an auditory sensory representation in posterior striatum emerges during a brief temporal window of associative learning in normal and hearing-impaired gerbils.Frontiers in systems neuroscience · 2025Article
- Developmental hearing loss-induced perceptual deficits are rescued by genetic restoration of cortical inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The human pupil and face encode sound affect and provide objective signatures of tinnitus and auditory hypersensitivity disorders.bioRxiv : the preprint server for biology · 2024Article
- Developmental hearing loss-induced perceptual deficits are rescued by cortical expression of GABAbioRxiv : the preprint server for biology · 2023Article
- The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles.The European journal of neuroscience · 2021Review
- Development of Auditory Cortex Circuits.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
- Disturbed Balance of Inhibitory Signaling Links Hearing Loss and Cognition.Frontiers in neural circuits · 2021Article
- Structural Alterations in a Rat Model of Short-Term Conductive Hearing Loss Are Associated With Reduced Resting State Functional Connectivity.Frontiers in systems neuroscience · 2021Article
- Developmental studies in fragile X syndrome.Journal of neurodevelopmental disorders · 2020Review
- Preserving Inhibition during Developmental Hearing Loss Rescues Auditory Learning and Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Pharmacological modulation of Kv3.1 mitigates auditory midbrain temporal processing deficits following auditory nerve damage.Scientific reports · 2017Article
- Developmental hearing loss impedes auditory task learning and performance in gerbils.Hearing research · 2017Article
- Differential maturation of vesicular glutamate and GABA transporter expression in the mouse auditory forebrain during the first weeks of hearing.Brain structure & function · 2016Article
- Persistent Thalamic Sound Processing Despite Profound Cochlear Denervation.Frontiers in neural circuits · 2016Article
- Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage.Neural plasticity · 2016Review
- Transient Hearing Loss Within a Critical Period Causes Persistent Changes to Cellular Properties in Adult Auditory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Central plasticity and dysfunction elicited by aural deprivation in the critical period.Frontiers in neural circuits · 2015Review
- Auditory training during development mitigates a hearing loss-induced perceptual deficit.Frontiers in systems neuroscience · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Inhibitory synapse dysfunction may contribute to many developmental brain disorders, including the secondary consequences of sensory deprivation. In fact, developmental hearing loss leads to a profound reduction in the strength of inhibitory postsynaptic currents (IPSCs) in the auditory cortex, and this deficit persists into adulthood. This finding is consistent with the general theory that the emergence of mature synaptic properties requires activity during development. Therefore, we tested the prediction that inhibitory strength can be restored following developmental hearing loss by boosting GABAergic transmission in vivo. Conductive or sensorineural hearing loss was induced surgically in gerbils prior to hearing onset and GABA agonists were then administered for one week. IPSCs were subsequently recorded from pyramidal neurons in a thalamocortical brain slice preparation. Administration of either a GABA(A) receptor a1 subunit specific agonist (zolpidem), or a selective GABA reuptake inhibitor (SGRI), rescued IPSC amplitude in hearing loss animals. Furthermore, this restoration persisted in adults, long after drug treatment ended. In contrast, a GABA(B) receptor agonist baclofen did not restore inhibitory strength. IPSCs could also be restored when SGRI administration began 3 weeks after sensory deprivation. Together, these results demonstrate long-lasting restoration of cortical inhibitory strength in the absence of normal experience. This suggests that in vivo GABA(A) receptor activation is sufficient to promote maturation, and this principle may extend to other developmental disorders associated with diminished inhibitory function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.