ArticlePloS one2013
Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responses.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.Cytokine · 2016Trial
- From animal models to NAMs: a paradigm shift in developmental immunotoxicity testing.Archives of toxicology · 2026Review
- TLR10 (CD290) Is a Regulator of Immune Responses in Human Plasmacytoid Dendritic Cells.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Molecular Mechanisms Behind the Role of Plasmacytoid Dendritic Cells in Systemic Sclerosis.Biology · 2023Review
- The early life education of the immune system: Moms, microbes and (missed) opportunities.Gut microbes · 2020Review
- Triggering of the cGAS-STING Pathway in Human Plasmacytoid Dendritic Cells Inhibits TLR9-Mediated IFN Production.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Plasmacytoid dendritic cell deficiency in neonates enhances allergic airway inflammation via reduced production of IFN-α.Cellular & molecular immunology · 2020Article
- Vaccine-Induced CD8Frontiers in immunology · 2020Review
- Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming.Journal of leukocyte biology · 2019Review
- Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection.Frontiers in immunology · 2019Review
- What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity.Frontiers in immunology · 2019Review
- Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells.Nature communications · 2018Article
- TLR agonist combinations that stimulate Th type I polarizing responses from human neonates.Innate immunity · 2018Article
- Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness?Frontiers in immunology · 2018Review
- Unique aspects of the perinatal immune system.Nature reviews. Immunology · 2017Review
- A distinct subset of plasmacytoid dendritic cells induces activation and differentiation of B and T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Continuous single cell imaging reveals sequential steps of plasmacytoid dendritic cell development from common dendritic cell progenitors.Scientific reports · 2016Article
- A CD2 high-expressing stress-resistant human plasmacytoid dendritic-cell subset.Immunology and cell biology · 2016Article
- Toll-like receptor 9-mediated protection of enterovirus 71 infection in mice is due to the release of danger-associated molecular patterns.Journal of virology · 2014Article
- Effect of influenza A infection on maturation and function of neonatal monocyte-derived dendritic cells.Viral immunology · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonates are highly susceptible to infectious diseases and defective antiviral pDC immune responses have been proposed to contribute to this phenomenon. Isolated cord blood pDCs innately responded to a variety of TLR7 and TLR9 dependent viruses, including influenza A virus (IAV), human immunodeficiency virus (HIV) or herpes-simplex virus (HSV) by efficiently producing IFN-α, TNF-α as well as chemokines. Interestingly, following activation by CpGA, but not viruses, cord pDCs tend to survive less efficiently. We found that a hallmark of pDCs in neonates is an extended CD2+pDCs compartment compared to adult pDCs without affecting the antiviral IFN-α response. Within CD2+pDCs, we identified a subpopulation expressing CD5 and responsible for IL-12p40 production, however this population is significantly decreased in cord blood compared to adult blood. Therefore, neonatal pDCs clearly display variation in phenotype and subset composition, but without major consequences for their antiviral responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.