ArticleWorld journal of gastroenterology2013
Tumor-infiltrating B cells come into vogue.
Article in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Upregulation of EMID1 Accelerates to a Favorable Prognosis and Immune Infiltration in Lung Adenocarcinoma.Journal of oncology · 2022Article
- Checkpoint molecules on infiltrating immune cells in colorectal tumor microenvironment.Frontiers in medicine · 2022Review
- Human Colorectal Carcinoma Infiltrating B Lymphocytes Are Active Secretors of the Immunoglobulin Isotypes A, G, and M.Cancers · 2019Article
- Article
- Tumor-infiltrating B cells producing antitumor active immunoglobulins in resected HCC prolong patient survival.Oncotarget · 2017Article
- Plasma cells in primary melanoma. Prognostic significance and possible role of IgA.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Advanced Proteogenomic Analysis Reveals Multiple Peptide Mutations and Complex Immunoglobulin Peptides in Colon Cancer.Journal of proteome research · 2015Article
- Comparative study of various subpopulations of cytotoxic cells in blood and ascites from patients with ovarian carcinoma.Contemporary oncology (Poznan, Poland) · 2015Article
- Tumor infiltrating B-cells are increased in prostate cancer tissue.Journal of translational medicine · 2014Article
- B cell-regulated immune responses in tumor models and cancer patients.Oncoimmunology · 2013Review
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphocyte infiltration into solid tumors has been recognized as a main determinator of positive prognosis. For the most part this is attributed to cytotoxic T cells capable of directly destroying malignant cells. However, when considering the complex composition of the human immune system, recent findings of Nielsen et al on a potentially central role of tumor-infiltrating B cells is not really surprising. In this commentary article, I want to highlight the enormous potential impact of this observation for basic and translational research, prognostic procedures and ultimately for the development of future therapeutic concepts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.