SynthesisWorld journal of gastroenterology2012
Itopride therapy for functional dyspepsia: a meta-analysis.
Synthesis in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07449689 (A Double-Blind Superiority Randomized Controlled Trial Comparing Acotiamide vs Itopride for Functional Dyspepsia Management), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Double-Blind Superiority Randomized Controlled Trial Comparing Acotiamide vs Itopride for Functional Dyspepsia Management
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Non-Chinese herbal medicines for functional dyspepsia.The Cochrane database of systematic reviews · 2023Pooled it
- Evidence-based clinical practice guidelines for functional dyspepsia 2021.Journal of gastroenterology · 2022Guideline
- Prokinetics for the treatment of functional dyspepsia: Bayesian network meta-analysis.BMC gastroenterology · 2017Pooled it
- The efficacy and safety of itopride in feeding intolerance of critically ill patients receiving enteral nutrition: a randomized, double-blind study.BMC gastroenterology · 2021Trial
- Effect of two-linked mutations of the FMO3 gene on itopride metabolism in Chinese healthy volunteers.European journal of clinical pharmacology · 2014Trial
- Impact of itopride on functional dyspepsia symptom progression: a multicenter noninterventional postregistration study.Therapeutic advances in gastroenterology · 2026Article
- Gastrointestinal Symptoms in Obesity Therapy: Mechanisms, Epidemiology, and Management Strategies.Biomedicines · 2025Review
- The mediating effect of circulating inflammatory proteins on the relationship between gut microbiota and FD: a bidirectional Mendelian randomization study.Scientific reports · 2024Article
- New Role of the Serotonin as a Biomarker of Gut-Brain Interaction.Life (Basel, Switzerland) · 2024Review
- Efficacy and safety of pantoprazole and itopride in patients with overlap of gastroesophageal reflux disease and dyspepsia: A prospective, open-label, single-arm pilot study.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Idiopathic Slow Transit Constipation: Pathophysiology, Diagnosis, and Management.Medicina (Kaunas, Lithuania) · 2024Review
- The efficacy and safety of itopride as an add-on therapy to a proton pump inhibitor in the treatment of gastroesophageal reflux disease.Przeglad gastroenterologiczny · 2024Article
- Efficacy and safety of itopride SR for upper gastrointestinal symptoms in patients with diabetic gastroparesis: real-world evidence from Pakistan.Drugs in context · 2023Article
- MODERN APPROACH TO DYSPEPSIA.Acta clinica Croatica · 2021Review
- Cobalt catalysed aminocarbonylation of thiols in batch and flow for the preparation of amides.RSC advances · 2021Article
- Dopamine receptors in emesis: Molecular mechanisms and potential therapeutic function.Pharmacological research · 2020Review
- Risk of domperidone induced severe ventricular arrhythmia.Scientific reports · 2020Article
- Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance.Journal of gastroenterology · 2020Article
- Clinical Practice Guidelines for Functional Dyspepsia in Korea.Journal of neurogastroenterology and motility · 2020Review
- Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis.Archives of medical science : AMS · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the therapeutic effects of itopride vs other drugs (placebo, domperidone, mosapride) for functional dyspepsia (FD).
methodsRandomized controlled trials (RCTs) of itopride for FD were retrieved from databases. Relevant information was extracted and analyzed, using the relative risk (RR) and weighted mean deviation, as appropriate. A random or fixed effect model was used, based on the heterogeneity of the included articles, and visual inspection of funnel plots was used to evaluate publication bias.
resultsNine RCTs enrolling 2620 FD cases were included; 1372 cases received itopride treatment and 1248 cases received placebo or other drugs (control groups). Compared with control groups, itopride had superior RR values of 1.11 [95%CI: (1.03, 1.19), P = 0.006], 1.21 [95%CI: (1.03, 1.44), P = 0.02], and 1.24 [95%CI: (1.01, 1.53), P = 0.04] for global patient assessment, postprandial fullness, and early satiety, respectively. For the Leeds Dyspepsia Questionnaire score, the weighted mean deviation was -1.38 [95%CI: (-1.75, -1.01), P < 0.01]. The incidence of adverse effects was similar in the itopride and control groups. The funnel plots for all indicators showed no evidence of publication bias.
conclusionItopride has good efficacy in terms of global patients assessment, postprandial fullness, and early satiety in the treatment of patients with FD and shows a low rate of adverse reactions. Itopride can greatly improve FD syndromes-score.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.