ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Mapping self-associating chromatin hubs identifies Id proteins as key determinants of exhausted CD8Nature immunology · 2026Article
- LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer.Cancer discovery · 2026Article
- Article
- Unravelling butyrate metabolism in sepsis: identification of key genes.BMC infectious diseases · 2025Article
- T-cell dysfunction during blinatumomab therapy in pediatric acute lymphoblastic leukemia.Blood advances · 2025Article
- The epigenetic landscape of fate decisions in T cells.Nature immunology · 2025Review
- Article
- Article
- Helix-Loop-Helix Proteins in Adaptive Immune Development.Frontiers in immunology · 2022Review
- Signaling networks controlling ID and E protein activity in T cell differentiation and function.Frontiers in immunology · 2022Review
- Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection.The Journal of experimental medicine · 2021Article
- The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates.The Journal of experimental medicine · 2021Review
- Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells.Cancer cell · 2020Article
- Heterogenous Populations of Tissue-Resident CD8Immunity · 2020Article
- The Transcriptional Regulator Id2 Is Critical for Adipose-Resident Regulatory T Cell Differentiation, Survival, and Function.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Remembering to remember: T cell memory maintenance and plasticity.Current opinion in immunology · 2019Review
- The Transcription Factor Runx2 Is Required for Long-Term Persistence of Antiviral CD8ImmunoHorizons · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
CD8(+) T cells play a crucial role in the clearance of intracellular pathogens through the generation of cytotoxic effector cells that eliminate infected cells and long-lived memory cells that provide enhanced protection against reinfection. We have previously shown that the inhibitor of E protein transcription factors, Id2, is necessary for accumulation of effector and memory CD8(+) T cells during infection. In this study, we show that CD8(+) T cells lacking Id2 did not generate a robust terminally differentiated killer cell lectin-like receptor G1 (KLRG1)(hi) effector population, but displayed a cell-surface phenotype and cytokine profile consistent with memory precursors, raising the question as to whether loss of Id2 impairs the differentiation and/or survival of effector memory cells. We found that deletion of Bim rescued Id2-deficient CD8(+) cell survival during infection. However, the dramatic reduction in KLRG1(hi) cells caused by loss of Id2 remained in the absence of Bim, such that Id2/Bim double-deficient cells form an exclusively KLRG1(lo)CD127(hi) memory precursor population. Thus, we describe a role for Id2 in both the survival and differentiation of normal CD8(+) effector and memory populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.