Evidence map›Paper›PMID 23325863›Full record

ReviewNeuro-oncology2013

Differentiating tumor recurrence from treatment necrosis: a review of neuro-oncologic imaging strategies.

Nishant Verma, Matthew C Cowperthwaite, Mark G Burnett, Mia K Markey

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03068520 (Imaging After Stereotactic Radiosurgery for Brain Metastases or Primary Tumor Can Hybrid PET-MRI Differentiate Between Radiation Effects and Disease ?), which is not on this map. Cited by 199 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03068520 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Imaging After Stereotactic Radiosurgery for Brain Metastases or Primary Tumor Can Hybrid PET-MRI Differentiate Between Radiation Effects and Disease ?

TypeinterventionalSponsorAssuta Medical CenterRan2017 to 2018Enrolled140ConditionsBrain TumorArmsPET MR
3 · Its place in the literature

Who cites it

199 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  12. Annals of nuclear medicine · 2025
    Trial
  13. Trial
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  15. Reirradiation of recurrent brain tumors: a review by the ESTRO CNS Focus Group.Clinical and translational radiation oncology · 2027
    Review
  16. Enhanced Glioblastoma Detection ThroughMagnetic resonance in medicine · 2026
    Article
  17. Article
  18. Review
  19. Article
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139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nishant VermaDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
Matthew C Cowperthwaite
Mark G Burnett
Mia K Markey

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Differentiating treatment-induced necrosis from tumor recurrence is a central challenge in neuro-oncology. These 2 very different outcomes after brain tumor treatment often appear similarly on routine follow-up imaging studies. They may even manifest with similar clinical symptoms, further confounding an already difficult process for physicians attempting to characterize a new contrast-enhancing lesion appearing on a patient's follow-up imaging. Distinguishing treatment necrosis from tumor recurrence is crucial for diagnosis and treatment planning, and therefore, much effort has been put forth to develop noninvasive methods to differentiate between these disparate outcomes. In this article, we review the latest developments and key findings from research studies exploring the efficacy of structural and functional imaging modalities for differentiating treatment necrosis from tumor recurrence. We discuss the possibility of computational approaches to investigate the usefulness of fine-grained imaging characteristics that are difficult to observe through visual inspection of images. We also propose a flexible treatment-planning algorithm that incorporates advanced functional imaging techniques when indicated by the patient's routine follow-up images and clinical condition.

Indexed as

Diagnostic ImagingNecrosisBrain NeoplasmsDiagnosis, DifferentialHumansNeoplasm Recurrence, LocalRadiation Injuries

Identifiers

PMID23325863
PMCPMC3635510

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.