ArticleDevelopment (Cambridge, England)2013
The microRNA miR-7 regulates Tramtrack69 in a developmental switch in Drosophila follicle cells.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Premature endocycling of Drosophila follicle cells causes pleiotropic defects in oogenesis.Genetics · 2024Article
- Sex-Biased Transcription Expression of Vitellogenins Reveals Fusion Gene and MicroRNA Regulation in the Sea Louse Caligus rogercresseyi.Marine biotechnology (New York, N.Y.) · 2024Article
- Finishing the egg.Genetics · 2024Article
- Identification and Characterization of Development-Related microRNAs in the Red Flour Beetle,International journal of molecular sciences · 2023Article
- miR-309a is a regulator of ovarian development in the oriental fruit fly Bactrocera dorsalis.PLoS genetics · 2022Article
- Drosophila miR-87 promotes dendrite regeneration by targeting the transcriptional repressor Tramtrack69.PLoS genetics · 2020Article
- Post-transcriptional regulation of insect metamorphosis and oogenesis.Cellular and molecular life sciences : CMLS · 2020Review
- Downregulation of homeodomain protein Cut is essential forDevelopment (Cambridge, England) · 2019Article
- Article
- Epigenetics: A key paradigm in reproductive health.Clinical and experimental reproductive medicine · 2016Review
- The ecdysone receptor signalling regulates microvilli formation in follicular epithelial cells.Cellular and molecular life sciences : CMLS · 2016Article
- Regulation of pattern formation and gene amplification during Drosophila oogenesis by the miR-318 microRNA.Genetics · 2015Article
- High-throughput sequencing reveals differential expression of miRNAs in intestine from sea cucumber during aestivation.PloS one · 2013Article
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Authors and funding
4 authors.
Funding
Abstract
Development in multicellular organisms includes both small incremental changes and major switches of cell differentiation and proliferation status. During Drosophila oogenesis, the follicular epithelial cells undergo two major developmental switches that cause global changes in the cell-cycle program. One, the switch from the endoreplication cycle to a gene-amplification phase, during which special genomic regions undergo repeated site-specific replication, is attributed to Notch downregulation, ecdysone signaling activation and upregulation of the zinc-finger protein Tramtrack69 (Ttk69). Here, we report that the microRNA miR-7 exerts an additional layer of regulation in this developmental switch by regulating Ttk69 transcripts. miR-7 recognizes the 3' UTR of ttk69 transcripts and regulates Ttk69 expression in a dose-dependent manner. Overexpression of miR-7 effectively blocks the switch from the endocycle to gene amplification through its regulation of ttk69. miR-7 and Ttk69 also coordinate other cell differentiation events, such as vitelline membrane protein expression, that lead to the formation of the mature egg. Our studies reveal the important role miR-7 plays in developmental decision-making in association with signal-transduction pathways.
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