ArticleJournal of the Royal Society, Interface2013
Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation.
Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Modelling Population-Level Hes1 Dynamics: Insights from a Multi-framework Approach.Bulletin of mathematical biology · 2025Article
- Incorporating spatial diffusion into models of bursty stochastic transcription.Journal of the Royal Society, Interface · 2025Article
- Spatially coordinated collective phosphorylation filters spatiotemporal noises for precise circadian timekeeping.iScience · 2023Article
- Systematic comparison of modeling fidelity levels and parameter inference settings applied to negative feedback gene regulation.PLoS computational biology · 2022Article
- Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey.International journal of molecular sciences · 2021Review
- A multiscale compartment-based model of stochastic gene regulatory networks using hitting-time analysis.The Journal of chemical physics · 2021Article
- Mathematical Modeling of ceRNA-Based Interactions.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Hierarchical algorithm for the reaction-diffusion master equation.The Journal of chemical physics · 2020Article
- Smart computational exploration of stochastic gene regulatory network models using human-in-the-loop semi-supervised learning.Bioinformatics (Oxford, England) · 2019Article
- Oscillations in well-mixed, deterministic feedback systems: Beyond ring oscillators.Journal of theoretical biology · 2019Article
- The Linear Noise Approximation for Spatially Dependent Biochemical Networks.Bulletin of mathematical biology · 2019Article
- Spatial Stochastic Intracellular Kinetics: A Review of Modelling Approaches.Bulletin of mathematical biology · 2019Review
- A 3D Multiscale Model to Explore the Role of EGFR Overexpression in Tumourigenesis.Bulletin of mathematical biology · 2019Article
- Reaction rates for reaction-diffusion kinetics on unstructured meshes.The Journal of chemical physics · 2017Article
- The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt.PLoS computational biology · 2017Article
- Stochastic Simulation Service: Bridging the Gap between the Computational Expert and the Biologist.PLoS computational biology · 2016Article
- Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process.PLoS biology · 2016Article
- Article
- Reaction rates for a generalized reaction-diffusion master equation.Physical review. E · 2016Article
- Accuracy of the Michaelis-Menten approximation when analysing effects of molecular noise.Journal of the Royal Society, Interface · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expression is not well understood. In this paper, we show that the observed experimental data and diverse differentiation responses can be explained by a spatial stochastic model of the Hes1 gene regulatory network. We also propose experiments to control the precise differentiation response using drug treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.