ArticleLearning & memory (Cold Spring Harbor, N.Y.)2013
The FMRFamide-related neuropeptide FLP-20 is required in the mechanosensory neurons during memory for massed training in C. elegans.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Neuropeptides Are Involved in Elicited Reversal Speed Plasticity inmicroPublication biology · 2026Article
- Neuropeptides Involved in Elicited Reversal Speed Plasticity inbioRxiv : the preprint server for biology · 2025Article
- Review
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- Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs.Frontiers in molecular neuroscience · 2021Review
- An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans.Neuron · 2018Article
- Habituation as an adaptive shift in response strategy mediated by neuropeptides.NPJ science of learning · 2017Article
- Neuropeptide-Driven Cross-Modal Plasticity following Sensory Loss in Caenorhabditis elegans.PLoS biology · 2016Article
- Modulation of Locomotion and Reproduction by FLP Neuropeptides in the Nematode Caenorhabditis elegans.PloS one · 2015Article
- Mechanosensory molecules and circuits in C. elegans.Pflugers Archiv : European journal of physiology · 2015Review
- Article
- C. elegans positive olfactory associative memory is a molecularly conserved behavioral paradigm.Neurobiology of learning and memory · 2014Article
- Family of FLP Peptides in Caenorhabditis elegans and Related Nematodes.Frontiers in endocrinology · 2014Review
- The FMRFamide-Like Peptide Family in Nematodes.Frontiers in endocrinology · 2014Review
- Mechanisms of plasticity in a Caenorhabditis elegans mechanosensory circuit.Frontiers in physiology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Lasting memories are likely to result from a lasting change in neurotransmission. In the nematode Caenorhabditis elegans, spaced training with a tap stimulus induces habituation to the tap that lasts for >24 h and is dependent on glutamate transmission, postsynaptic AMPA receptors, and CREB. Here we describe a distinct, presynaptic mechanism for a shorter lasting memory for tap habituation induced by massed training. We report that a FMRFamide-related peptide (FMRF = Phe-Met-Arg-Phe-NH(2)), FLP-20, is critical for memory lasting 12 h following massed training, but is not required for other forms of memory. Massed training correlated with a flp-20-dependent increase in synaptobrevin tagged with green fluorescent protein in the presynaptic terminals of the PLM mechanosensory neurons that followed the timeline of the memory trace. We also demonstrated that flp-20 is required specifically in the mechanosensory neurons for memory 12 h after massed training. These findings show that within the same species and form of learning, memory is induced by distinct mechanisms to create a lasting alteration in neurotransmission that is dependent upon the temporal pattern of training: memory of spaced training results from postsynaptic changes in the interneurons of the neural circuit, whereas memory of massed training results from presynaptic changes in the mechanosensory neurons of the neural circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.