Evidence map›Paper›PMID 23325690›Full record

ArticleJournal of virology2013

Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus?

Brian M Sullivan, Megan J Welch, Greg Lemke, Michael B A Oldstone

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. TAM receptor signaling in immune homeostasis.Annual review of immunology · 2015
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Brian M SullivanViral-Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Megan J Welch
Greg Lemke
Michael B A Oldstone
Ecologie Microbienne Lyon · FRSalk Institute for Biological Studies · USScripps Research Institute · US

Funding

PATHOGENESIS OF PERSISTENT VIRAL INFECTIONR01AI009484 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI OLDSTONE, MICHAEL B · 1985 to 2016
$7.2M
TAM Receptors and Virus InfectionR01AI101400 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI DIAMOND, MICHAEL S, KLEIN, ROBYN S. · 2012 to 2021
$5.8M
Virology of the Central Nervous SystemT32NS041219 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI ELDER, JOHN H · 2001 to 2010
$2.4M
PATHOGENESIS OF PERSISTENT VIRAL INFECTIONR37AI009484 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI OLDSTONE, MICHAEL B · 1988 to 1997
–
NIAID NIH HHS AI09484NIAID NIH HHS AI101400NIAID NIH HHS R01 AI009484NIAID NIH HHS R01 AI101400NINDS NIH HHS 2T32 NS041219-11NINDS NIH HHS T32 NS041219
6 · The paper itself

Abstract

A recent publication indicated that overexpression of Axl, a cellular receptor that negatively regulates Toll-like receptor signaling, enhanced the entry of viruses pseudotyped with the glycoprotein of lymphocytic choriomeningitis virus (LCMV) in vitro. In testing the biological relevance of these observations, we found differences in neither viral kinetics between LCMV infections of Axl(-/-) and wild-type mice nor T-cell responses prior to spontaneous viral clearance. Thus, Axl is not required for productive LCMV infection of mice.

Indexed as

Virus InternalizationAnimalsArenaviridae InfectionsArenavirusAxl Receptor Tyrosine KinaseFluorescenceMiceMice, Inbred C57BLMice, KnockoutProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesAxl Receptor Tyrosine KinaseProto-Oncogene ProteinsReceptor Protein-Tyrosine Kinases

Identifiers

PMID23325690
PMCPMC3624193
OpenAlexW2096674075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.