ArticleMethods in molecular biology (Clifton, N.J.)2013
RNAi-mediated gene function analysis in skin.
Article in Methods in molecular biology (Clifton, N.J.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Targeted regeneration of post-radiation epithelium without promoting cancer recurrence.Research square · 2026Article
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- Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin.The EMBO journal · 2024Article
- In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.Nature communications · 2023Article
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- Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer.Cancer discovery · 2022Article
- THY1-mediated mechanisms converge to drive YAP activation in skin homeostasis and repair.Nature cell biology · 2022Article
- Repeated mutation of a developmental enhancer contributed to human thermoregulatory evolution.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Selective Translation of Cell Fate Regulators Mediates Tolerance to Broad Oncogenic Stress.Cell stem cell · 2020Article
- Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers.Cell stem cell · 2020Article
- The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis.Development (Cambridge, England) · 2019Article
- Oncogenic activation of PI3K induces progenitor cell differentiation to suppress epidermal growth.Nature cell biology · 2018Article
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- Epidermal development, growth control, and homeostasis in the face of centrosome amplification.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- In vivo RNAi screens: concepts and applications.Trends in immunology · 2015Review
- Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN.Nature cell biology · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
We have recently developed a method for RNAi-mediated gene function analysis in skin (Beronja et al., Nat Med 16:821-827, 2010). It employs ultrasound-guided in utero microinjections of lentivirus into the amniotic cavity of embryonic day 9 mice, which result in rapid, efficient, and stable transduction into mouse skin. Our technique greatly extends the available molecular and genetic toolbox for comprehensive functional examination of outstanding problems in epidermal biology. In its simplest form, as a single-gene function analysis via shRNA-mediated gene knockdown, our technique requires no animal mating and may need as little as only a few days between manipulation and phenotypic analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.