ArticleDrug safety2013
Transplantation for acute liver failure in patients exposed to NSAIDs or paracetamol (acetaminophen): the multinational case-population SALT study.
Article in Drug safety, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Pooled it
- Oral paracetamol (acetaminophen) for cancer pain.The Cochrane database of systematic reviews · 2017Pooled it
- Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults.The Cochrane database of systematic reviews · 2016Pooled it
- Paracetamol (acetaminophen) for acute treatment of episodic tension-type headache in adults.The Cochrane database of systematic reviews · 2016Pooled it
- Adverse events associated with single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews.The Cochrane database of systematic reviews · 2015Pooled it
- Computational Insights into the Structural Basis for Reduced Hepatotoxicity of Novel Nonopioid Analgesics.ChemMedChem · 2025Article
- Article
- Article
- NLRP3 deficiency protects against acetaminophen‑induced liver injury by inhibiting hepatocyte pyroptosis.Molecular medicine reports · 2024Article
- Review
- Potential deleterious effects of paracetamol dose regime used in Nigeria versus that of the United States of America.Toxicology reports · 2022Review
- Is There an Increased Risk of Hepatotoxicity with Metamizole? A Comparative Cohort Study in Incident Users.Drug safety · 2021Article
- Article
- Comparison of Efficacy of Ketoprofen and Ibuprofen in Treating Pain in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.Pain and therapy · 2021Article
- Garlic Alleviates the Injurious Impact of Cyclosporine-A in Male Rats through Modulation of Fibrogenic and Steroidogenic Genes.Animals : an open access journal from MDPI · 2020Article
- Does Ibuprofen Worsen COVID-19?Drug safety · 2020Article
- Liver injury induced by paracetamol and challenges associated with intentional and unintentional use.World journal of hepatology · 2020Review
- Coronary Risks Associated with Diclofenac and Other NSAIDs: An Update.Drug safety · 2020Review
- A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.Gastroenterology · 2019Article
- Previous Drug Exposure in Patients Hospitalised for Acute Liver Injury: A Case-Population Study in the French National Healthcare Data System.Drug safety · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 12 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost NSAIDs are thought to be able to cause hepatic injury and acute liver failure (ALF), but the event rates of those leading to transplantation (ALFT) remain uncertain.
objectivesThe aim of the study was to estimate population event rates for NSAID-associated ALFT
methodsThis was a case-population study of ALFT in 57 eligible liver transplant centres in seven countries (France, Greece, Ireland, Italy, The Netherlands, Portugal and the UK). Cases were all adults registered from 2005 to 2007 for a liver transplant following ALFT without identified clinical aetiology, exposed to an NSAID or paracetamol (acetaminophen) within 30 days before the onset of clinical symptoms. NSAID and paracetamol population exposures were assessed using national sales data from Intercontinental Marketing Services (IMS). Risk was estimated as the rate of ALFT per million treatment-years (MTY).
resultsIn the 52 participating centres, 9479 patients were registered for transplantation, with 600 for ALFT, 301 of whom, without clinical aetiology, had been exposed to a drug within 30 days. Of these 301 patients, 40 had been exposed to an NSAID and 192 to paracetamol (81 of whom were without overdose). Event rates per MTY were 1.59 (95 % CI 1.1-2.2) for all NSAIDs pooled, 2.3 (95 % CI 1.2-3.9) for ibuprofen, 1.9 (95 % CI 0.8-3.7) for nimesulide, 1.6 (95 % CI 0.6-3.4) for diclofenac and 1.6 (95 % CI 0.3-4.5) for ketoprofen. For paracetamol, the event rate was 3.3 per MTY (95 % CI 2.6-4.1) without overdoses and 7.8 (95 % CI 6.8-9.0) including overdoses.
conclusionsALF leading to registration for transplantation after exposure to an NSAID was rare, with no major difference between NSAID. Non-overdose paracetamol-exposed liver failure was twice more common than NSAID-exposed liver failure.
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Registered trials
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