ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2013
Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Non-invasive ovulation tracking enables genetic engineering in wild rodents.Cell reports methods · 2026Article
- A Reassessment of Sarcopenia from a Redox Perspective as a Basis for Preventive and Therapeutic Interventions.International journal of molecular sciences · 2025Review
- Comparison of age-related inflammation and oxidative stress in two lemur species.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Auditory brainstem responses in two closely related Peromyscus species (Peromyscus leucopus and Peromyscus maniculatus).The Journal of the Acoustical Society of America · 2025Article
- SHLP6: a novel NLRP3 and Cav1 modulating agent in Cu-induced oxidative stress and neurodegeneration.Frontiers in molecular neuroscience · 2025Article
- Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2.Antioxidants (Basel, Switzerland) · 2023Article
- Homeostasis of carbohydrates and reactive oxygen species is critically changed in the brain of middle-aged mice: Molecular mechanisms and functional reasons.BBA advances · 2023Article
- Physiological Evidence for Delayed Age-related Hearing Loss in Two Long-lived Rodent Species (Peromyscus leucopus and P. californicus).Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Regulation of Age-Related Protein Toxicity.Frontiers in cell and developmental biology · 2021Review
- The Lipidome Fingerprint of Longevity.Molecules (Basel, Switzerland) · 2020Review
- Genomes, expression profiles, and diversity of mitochondria of the White-footed Deermouse Peromyscus leucopus, reservoir of Lyme disease and other zoonoses.Scientific reports · 2019Article
- Astaxanthin Attenuates Environmental Tobacco Smoke-Induced Cognitive Deficits: A Critical Role of p38 MAPK.Marine drugs · 2019Article
- An updated genetic map of Peromyscus with chromosomal assignment of linkage groups.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis.Redox biology · 2018Article
- Aconitine inhibits the proliferation of hepatocellular carcinoma by inducing apoptosis.International journal of clinical and experimental pathology · 2018Article
- Ranolazine promotes muscle differentiation and reduces oxidative stress in C2C12 skeletal muscle cells.Endocrine · 2017Article
- Article
- Peromyscus transcriptomics: Understanding adaptation and gene expression plasticity within and between species of deer mice.Seminars in cell & developmental biology · 2017Review
- The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging.Aging cell · 2015Article
- Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Comparing biological processes in closely related species with divergent life spans is a powerful approach to study mechanisms of aging. The oxidative stress hypothesis of aging predicts that longer-lived species would have lower reactive oxygen species (ROS) generation and/or an increased antioxidant capacity, resulting in reduced oxidative damage with age than in shorter-lived species. In this study, we measured ROS generation in the young adult animals of the long-lived white-footed mouse, Peromyscus leucopus (maximal life span potential, MLSP = 8 yr) and the common laboratory mouse, Mus musculus (C57BL/6J strain; MLSP = 3.5 yr). Consistent with the hypothesis, our results show that skeletal muscle mitochondria from adult P. leucopus produce less ROS (superoxide and hydrogen peroxide) compared with M. musculus. Additionally, P. leucopus has an increase in the activity of antioxidant enzymes superoxide dismutase 1, catalase, and glutathione peroxidase 1 at young age. P. leucopus compared with M. musculus display low levels of lipid peroxidation (isoprostanes) throughout life; however, P. leucopus although having elevated protein carbonyls at a young age, the accrual of protein oxidation with age is minimal in contrast to the linear increase in M. musculus. Altogether, the results from young animals are in agreement with the predictions of the oxidative stress hypothesis of aging with the exception of protein carbonyls. Nonetheless, the age-dependent increase in protein carbonyls is more pronounced in short-lived M. musculus, which supports enhanced protein homeostasis in long-lived P. leucopus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.