ArticleAmerican journal of physiology. Cell physiology2013
Contribution of increased VEGF receptors to hypoxic changes in fetal ovine carotid artery contractile proteins.
Article in American journal of physiology. Cell physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Receptor Tyrosine Kinase: Still an Interesting Target to Inhibit the Proliferation of Vascular Smooth Muscle Cells.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2023Review
- Postnatal development alters functional compartmentalization of myosin light chain kinase in ovine carotid arteries.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Hypoxic modulation of fetal vascular MLCK abundance, localization, and function.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Exposure to Blast Overpressure Impairs Cerebral Microvascular Responses and Alters Vascular and Astrocytic Structure.Journal of neurotrauma · 2019Article
- Anti-vasospastic Effects of Epidermal Growth Factor Receptor Inhibitors After Subarachnoid Hemorrhage in Mice.Molecular neurobiology · 2019Article
- Fetal Cerebrovascular Maturation: Effects of Hypoxia.Seminars in pediatric neurology · 2018Review
- Chronic hypoxia alters fetal cerebrovascular responses to endothelin-1.American journal of physiology. Cell physiology · 2017Article
- Imatinib attenuates cerebrovascular injury and phenotypic transformation after intracerebral hemorrhage in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Chronic cerebrovascular dysfunction after traumatic brain injury.Journal of neuroscience research · 2016Review
- Vascular Endothelial Growth Factor as a Prognostic Parameter in Subjects with "Plateau Red Face".High altitude medicine & biology · 2015Article
- Role of the sympathetic autonomic nervous system in hypoxic remodeling of the fetal cerebral vasculature.Journal of cardiovascular pharmacology · 2015Review
- VEGF receptors mediate hypoxic remodeling of adult ovine carotid arteries.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Smooth muscle phenotype switching in blast traumatic brain injury-induced cerebral vasospasm.Translational stroke research · 2014Review
- Maternal food restriction modulates cerebrovascular structure and contractility in adult rat offspring: effects of metyrapone.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- The fetal cerebral circulation: three decades of exploration by the LLU Center for Perinatal Biology.Advances in experimental medicine and biology · 2014Article
- Maturation and differentiation of the fetal vasculature.Clinical obstetrics and gynecology · 2013Review
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Recent studies suggest that vascular endothelial growth factor (VEGF) can modulate smooth muscle phenotype and, consequently, the composition and function of arteries upstream from the microcirculation, where angiogenesis occurs. Given that hypoxia potently induces VEGF, the present study explores the hypothesis that, in fetal arteries, VEGF contributes to hypoxic vascular remodeling through changes in abundance, organization, and function of contractile proteins. Pregnant ewes were acclimatized at sea level or at altitude (3,820 m) for the final 110 days of gestation. Endothelium-denuded carotid arteries from full-term fetuses were used fresh or after 24 h of organ culture in a physiological concentration (3 ng/ml) of VEGF. After 110 days, hypoxia had no effect on VEGF abundance but markedly increased abundance of the Flk-1 (171%) and Flt-1 (786%) VEGF receptors. Hypoxia had no effect on smooth muscle α-actin (SMαA), decreased myosin light chain (MLC) kinase (MLCK), and increased 20-kDa regulatory MLC (MLC(20)) abundances. Hypoxia also increased MLCK-SMαA, MLC(20)-SMαA, and MLCK-MLC(20) colocalization. Compared with hypoxia, organ culture with VEGF produced the same pattern of changes in contractile protein abundance and colocalization. Effects of VEGF on colocalization were blocked by the VEGF receptor antagonists vatalanib (240 nM) and dasatinib (6.3 nM). Thus, through increases in VEGF receptor density, hypoxia can recruit VEGF to help mediate remodeling of fetal arteries upstream from the microcirculation. The results support the hypothesis that VEGF contributes to hypoxic vascular remodeling through changes in abundance, organization, and function of contractile proteins.
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Registered trials
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