ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via α7 nicotinic acetylcholine receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 33 citations in OpenAlex.
- Hypertension Induces Cognitive Impairment and Alterations of Acetylcholine Receptor mRNA Expression in the Hippocampus and Cortex of Mice.Neuromolecular medicine · 2025Article
- Hippocampal GABAergic interneurons and memory.Neuron · 2023Review
- Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo.Nature communications · 2022Article
- Theta patterns of stimulation induce synaptic and intrinsic potentiation in O-LM interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nicotinic receptor activation induces NMDA receptor independent long-term potentiation of glutamatergic signalling in hippocampal oriens interneurons.The Journal of physiology · 2021Article
- Synaptic Plasticity in Cortical Inhibitory Neurons: What Mechanisms May Help to Balance Synaptic Weight Changes?Frontiers in cellular neuroscience · 2020Review
- Hippocampal Stratum Oriens Somatostatin-Positive Cells Undergo CB1-Dependent Long-Term Potentiation and Express Endocannabinoid Biosynthetic Enzymes.Molecules (Basel, Switzerland) · 2019Article
- Memory Prosthesis: Is It Time for a Deep Neuromimetic Computing Approach?Frontiers in neuroscience · 2019Article
- Calcium Dynamics in Dendrites of Hippocampal CA1 Interneurons in Awake Mice.Frontiers in cellular neuroscience · 2019Article
- Possible Implication of the CA2 Hippocampal Circuit in Social Cognition Deficits Observed in the Neuroligin 3 Knock-Out Mouse, a Non-Syndromic Animal Model of Autism.Frontiers in psychiatry · 2019Article
- T-type calcium channels contribute to NMDA receptor independent synaptic plasticity in hippocampal regular-spiking oriens-alveus interneurons.The Journal of physiology · 2017Article
- Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo.Brain structure & function · 2017Article
- α7-nAChR agonist enhances neural plasticity in the hippocampus via a GABAergic circuit.Journal of neurophysiology · 2016Article
- Layer-specific cholinergic control of human and mouse cortical synaptic plasticity.Nature communications · 2016Article
- Dendritic calcium nonlinearities switch the direction of synaptic plasticity in fast-spiking interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Long-term potentiation in hippocampal oriens interneurons: postsynaptic induction, presynaptic expression and evaluation of candidate retrograde factors.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
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3 authors at 1 institution in 1 country.
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Abstract
In the hippocampus, at excitatory synapses between principal cell and oriens/alveus (O/A) interneurons, a particular form of NMDA-independent long-term synaptic plasticity (LTP) has been described (Lamsa et al., 2007). This type of LTP occurs when presynaptic activation coincides with postsynaptic hyperpolarization. For this reason it has been named "anti-Hebbian" to distinguish from the classical Hebbian type of associative learning where presynaptic glutamate release coincides with postsynaptic depolarization. The different voltage dependency of LTP induction is thought to be mediated by calcium-permeable (CP) AMPA receptors that, due to polyamine-mediated rectification, favor calcium entry at hyperpolarized potentials. Here, we report that the induction of this form of LTP needs CP-α7 nicotinic acetylcholine receptors (nAChRs) that, like CP-AMPARs, exhibit a strong inward rectification because of polyamine block at depolarizing potentials. We found that high-frequency stimulation of afferent fibers elicits synaptic currents mediated by α7 nAChRs. Hence, LTP was prevented by α7 nAChR antagonists dihydro-β-erythroidine and methyllycaconitine (MLA) and was absent in α7(-/-) mice. In addition, in agreement with previous observations (Le Duigou and Kullmann, 2011), in a minority of O/A interneurons in MLA-treated hippocampal slices from WT animals and α7(-/-) mice, a form of LTP probably dependent on the activation of group I metabotropic glutamate receptors was observed. These data indicate that, in O/A interneurons, anti-Hebbian LTP critically depends on cholinergic signaling via α7 nAChR. This may influence network oscillations and information processing.
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