ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Layer III neurons control synchronized waves in the immature cerebral cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
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- Network state transitions during cortical development.Nature reviews. Neuroscience · 2024Review
- Reelin Regulates Developmental Desynchronization Transition of Neocortical Network Activity.Biomolecules · 2024Article
- Synchronous excitation in the superficial and deep layers of the medial entorhinal cortex precedes early sharp waves in the neonatal rat hippocampus.Frontiers in cellular neuroscience · 2024Article
- KCNQ2 channels regulate the population activity of neonatal GABAergic neuronsFrontiers in neurology · 2023Article
- To Analyze the Application Value of Perioperative Nursing Care in Patients with Resected Brain Tumor Accompanied with Epileptic Symptoms under Cortical Electrocorticography Monitoring.Journal of healthcare engineering · 2022Article
- Somatostatin interneurons activated by 5-HTeLife · 2021Article
- Propagating wave activity in a tangential cortical slice.Neuroreport · 2020Article
- Micro Three-Dimensional Neuronal Cultures Generate Developing Cortex-Like Activity Patterns.Frontiers in neuroscience · 2020Article
- Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices.Frontiers in systems neuroscience · 2020Review
- Distinct Synchronous Network Activity During the Second Postnatal Week of Medial Entorhinal Cortex Development.Frontiers in cellular neuroscience · 2020Article
- Early-generated interneurons regulate neuronal circuit formation during early postnatal development.eLife · 2019Article
- Emergence of Coordinated Activity in the Developing Entorhinal-Hippocampal Network.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- SamuROI, a Python-Based Software Tool for Visualization and Analysis of Dynamic Time Series Imaging at Multiple Spatial Scales.Frontiers in neuroinformatics · 2017Article
- Modulation of Neocortical Development by Early Neuronal Activity: Physiology and Pathophysiology.Frontiers in cellular neuroscience · 2017Review
- Spontaneous Neuronal Activity in Developing Neocortical Networks: From Single Cells to Large-Scale Interactions.Frontiers in neural circuits · 2016Review
- Glutamatergic system controls synchronization of spontaneous neuronal activity in the murine neonatal entorhinal cortex.Pflugers Archiv : European journal of physiology · 2015Article
- Large-scale spatiotemporal spike patterning consistent with wave propagation in motor cortex.Nature communications · 2015Article
- Patterns of Spontaneous Local Network Activity in Developing Cerebral Cortex: Relationship to Adult Cognitive Function.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Correlated spiking activity prevails in immature cortical networks and is believed to contribute to neuronal circuit maturation; however, its spatiotemporal organization is not fully understood. Using wide-field calcium imaging from acute whole-brain slices of rat pups on postnatal days 1-6, we found that correlated spikes were initiated in the anterior part of the lateral entorhinal cortex and propagated anteriorly to the frontal cortex and posteriorly to the medial entorhinal cortex, forming traveling waves that engaged almost the entire cortex. The waves were blocked by ionotropic glutamatergic receptor antagonists but not by GABAergic receptor antagonists. During wave events, glutamatergic and GABAergic synaptic inputs were balanced and induced UP state-like depolarization. Magnified monitoring with cellular resolution revealed that the layer III neurons were first activated when the waves were initiated. Consistent with this finding, layer III contained a larger number of neurons that were autonomously active, even under a blockade of synaptic transmission. During wave propagation, the layer III neurons constituted a leading front of the wave. The waves did not enter the parasubiculum; however, in some cases, they were reflected at the parasubicular border and propagated back in the opposite direction. During this reflection process, the layer III neurons in the medial entorhinal cortex maintained persistent activity. Thus, our data emphasize the role of layer III in early network behaviors and provide insight into the circuit mechanisms through which cerebral cortical networks maturate.
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