ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Functional specialization of parallel motion detection circuits in the fly.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed.
- Model organisms and systems in neuroethology: one hundred years of history and a look into the future.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- SLoN: a spiking looming perception network exploiting neural encoding and processing in ON/OFF channels.Frontiers in neuroscience · 2024Article
- Modelling Drosophila motion vision pathways for decoding the direction of translating objects against cluttered moving backgrounds.Biological cybernetics · 2020Article
- Mechanism for analogous illusory motion perception in flies and humans.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- How fly neurons compute the direction of visual motion.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- Neural circuitry of social learning in Drosophila requires multiple inputs to facilitate inter-species communication.Communications biology · 2019Article
- The Neuronal Basis of an Illusory Motion Percept Is Explained by Decorrelation of Parallel Motion Pathways.Current biology : CB · 2018Article
- Glutamate Signaling in the Fly Visual System.iScience · 2018Article
- Elementary Motion Detection in Drosophila: Algorithms and Mechanisms.Annual review of vision science · 2018Review
- A biophysical mechanism for preferred direction enhancement in fly motion vision.PLoS computational biology · 2018Article
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- Full reconstruction of large lobula plate tangential cells in Drosophila from a 3D EM dataset.PloS one · 2018Article
- Generation and Evolution of Neural Cell Types and Circuits: Insights from the Drosophila Visual System.Annual review of genetics · 2017Review
- Characterization of the first-order visual interneurons in the visual system of the bumblebee (Bombus terrestris).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- A common directional tuning mechanism ofeLife · 2017Article
- Visual Circuits for Direction Selectivity.Annual review of neuroscience · 2017Review
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- Direction Selectivity in Drosophila Emerges from Preferred-Direction Enhancement and Null-Direction Suppression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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4 authors.
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Abstract
In the fly Drosophila melanogaster, photoreceptor input to motion vision is split into two parallel pathways as represented by first-order interneurons L1 and L2 (Rister et al., 2007; Joesch et al., 2010). However, how these pathways are functionally specialized remains controversial. One study (Eichner et al., 2011) proposed that the L1-pathway evaluates only sequences of brightness increments (ON-ON), while the L2-pathway processes exclusively brightness decrements (OFF-OFF). Another study (Clark et al., 2011) proposed that each of the two pathways evaluates both ON-ON and OFF-OFF sequences. To decide between these alternatives, we recorded from motion-sensitive neurons in flies in which the output from either L1 or L2 was genetically blocked. We found that blocking L1 abolishes ON-ON responses but leaves OFF-OFF responses intact. The opposite was true, when the output from L2 was blocked. We conclude that the L1 and L2 pathways are functionally specialized to detect ON-ON and OFF-OFF sequences, respectively.
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