ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Temperature integration at the AC thermosensory neurons in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Understanding animal temperature sensation: from molecular thermosensors to physiological impacts.Science China. Life sciences · 2026Review
- Article
- Review
- Molecular and Neural Mechanisms of Temperature Preference Rhythm inJournal of biological rhythms · 2023Review
- How Temperature Influences Sleep.International journal of molecular sciences · 2022Review
- A thermometer circuit for hot temperature adjusts Drosophila behavior to persistent heat.Current biology : CB · 2022Article
- Dorsal clock networks drive temperature preference rhythms in Drosophila.Cell reports · 2022Article
- Review
- Peripheral Sensory Organs Contribute to Temperature Synchronization of the Circadian Clock inFrontiers in physiology · 2021Review
- Identification, Characterization and Expression Analysis of TRP Channel Genes in the Vegetable Pest,Insects · 2020Article
- Stochastic and Arbitrarily Generated Input Patterns to the Mushroom Bodies Can Serve as Conditioned Stimuli inFrontiers in physiology · 2020Article
- Neural Code for Ambient Heat Detection in Elaterid Beetles.Frontiers in behavioral neuroscience · 2020Article
- Daytime colour preference in Drosophila depends on the circadian clock and TRP channels.Nature · 2019Article
- Review
- Temperature synchronization of theCommunications biology · 2019Article
- An Automated Method to Determine the Performance of Drosophila in Response to Temperature Changes in Space and Time.Journal of visualized experiments : JoVE · 2018Article
- Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals.Genes & development · 2018Article
- How Many Clocks, How Many Times? On the Sensory Basis and Computational Challenges of Circadian Systems.Frontiers in behavioral neuroscience · 2018Review
- The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature.International journal of molecular sciences · 2017Review
- Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Temperature sensation has a strong impact on animal behavior and is necessary for animals to avoid exposure to harmful temperatures. It is now well known that thermoTRP (transient receptor potential) channels in thermosensory neurons detect a variable range of temperature stimuli. However, little is known about how a range of temperature information is relayed and integrated in the neural circuits. Here, we show novel temperature integration between two warm inputs via Drosophila TRPA channels, TRPA1 and Pyrexia (Pyx). The internal AC (anterior cell) thermosensory neurons, which express TRPA1, detect warm temperatures and mediate temperature preference behavior. We found that the AC neurons were activated twice when subjected to increasing temperatures. The first response was at ∼25°C via TRPA1 channel, which is expressed in the AC neurons. The second response was at ∼27°C via the second antennal segments, indicating that the second antennal segments are involved in the detection of warm temperatures. Further analysis reveals that pyx-Gal4-expressing neurons have synapses on the AC neurons and that mutation of pyx eliminates the second response of the AC neurons. These data suggest that AC neurons integrate both their own TRPA1-dependent temperature responses and a Pyx-dependent temperature response from the second antennal segments. Our data reveal the first identification of temperature integration, which combines warm temperature information from peripheral to central neurons and provides the possibility that temperature integration is involved in the plasticity of behavioral outputs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.