ArticleThe Journal of clinical investigation1990
Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen.
Article in The Journal of clinical investigation, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 172 citations in OpenAlex.
- Calreticulin-From the Endoplasmic Reticulum to the Plasma Membrane-Adventures of a Wandering Protein.Cancers · 2025Review
- James Neil Gilliam, MD-the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease.Annals of translational medicine · 2018Article
- Overexpression of a Triticum aestivum Calreticulin gene (TaCRT1) Improves Salinity Tolerance in Tobacco.PloS one · 2015Article
- Loss of all three calreticulins, CRT1, CRT2 and CRT3, causes enhanced sensitivity to water stress in Arabidopsis.Plant cell reports · 2013Article
- Calreticulin binds preferentially with B cell linear epitopes of Ro60 kD autoantigen, enhancing recognition by anti-Ro60 kD autoantibodies.Clinical and experimental immunology · 2003Article
- Delayed activation of the store-operated calcium current induced by calreticulin overexpression in RBL-1 cells.Molecular biology of the cell · 1998Article
- Release of calreticulin from neutrophils may alter C1q-mediated immune functions.The Biochemical journal · 1997Article
- Mapping of the gene for calreticulin (Calr) to mouse chromosome 8.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Autoantigens interact with cis-acting elements of rubella virus RNA.Journal of virology · 1996Article
- Overexpression of calreticulin increases the Ca2+ capacity of rapidly exchanging Ca2+ stores and reveals aspects of their lumenal microenvironment and function.The Journal of cell biology · 1995Article
- Purification of antigenically intact Ro ribonucleoproteins; biochemical and immunological evidence that the 52-kD protein is not a Ro protein.Clinical and experimental immunology · 1995Article
- Identification of calreticulin as a rubella virus RNA binding protein.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Characterization of cDNA for murine tripeptidyl-peptidase II reveals alternative splicing.The Biochemical journal · 1994Article
- Collectins, collectin receptors and the lectin pathway of complement activation.Clinical and experimental immunology · 1994Review
- Calreticulin: not just another calcium-binding protein.Molecular and cellular biochemistry · 1994Review
- Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.The Journal of experimental medicine · 1994Article
- Epitope mapping with synthetic peptides of 52-kD SSA/Ro protein reveals heterogeneous antibody profiles in human autoimmune sera.Clinical and experimental immunology · 1994Article
- Covalent structure of bovine brain calreticulin.The Biochemical journal · 1994Article
- Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro/SSA-positive patients in rabbit hearts.The Journal of clinical investigation · 1994Article
- Mammalian lectins in activation and clearance mechanisms involving the complement system.Springer seminars in immunopathology · 1994Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Ro/SS-A antibodies are found in a number of human autoimmune disorders including Sjogren's syndrome and several systemic lupus erythematosus-related disorders. These heterogeneous autoantibodies are known to recognize several distinct cellular antigens. With synthetic oligonucleotides corresponding to amino acid sequence information we have isolated a full-length cDNA clone which encodes a human Ro ribonucleoprotein autoantigen. The 1,890-base pair clone contains an open reading frame that encodes a 417-amino acid, 48-kD polypeptide that migrates aberrantly at 60 kD by SDS-PAGE. Rabbit antibodies raised against this protein's recently described amino-terminal epitope react with a previously identified 52-kD human Ro protein and immunoprecipitate the human cytoplasmic RNAs. Ultraviolet light cross-linking studies suggest that this Ro protein binds each of the four major human cytoplasmic RNAs. The deduced amino acid sequence is 63% homologous to an Onchocerca volvulus antigen. Southern filter hybridization analysis indicates that this gene is not highly polymorphic and exists as a single copy in the human genome. Chromosomal localization studies place this gene on the short arm of chromosome 19 near the gene encoding the low density lipoprotein receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.