ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2013
Developmental localization of nephrin in zebrafish and medaka pronephric glomerulus.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Glomage: A Multimodal Platform for High-Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- gdf11 is required for pronephros/cloaca development through targeting TGF-β signaling.Scientific reports · 2025Article
- Urinary nephrin - An emerging novel biomarker in early detection of diabetic nephropathy: A review.Bioinformation · 2025Article
- Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish.Journal of developmental biology · 2023Review
- A zebrafish model of congenital nephrotic syndrome of the Finnish type.Frontiers in cell and developmental biology · 2022Article
- Nephrocytes are part of the spectrum of filtration epithelial diversity.Cell and tissue research · 2020Article
- The human nephrin YThe Journal of biological chemistry · 2019Article
- Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B.Scientific reports · 2018Article
- Evolutionary morphology of podocytes and primary urine-producing apparatus.Anatomical science international · 2017Review
- Avian Podocytes, Which Lack Nephrin, Use Adherens Junction Proteins at Intercellular Junctions.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus.EBioMedicine · 2014Article
- Using zebrafish to study podocyte genesis during kidney development and regeneration.Genesis (New York, N.Y. : 2000) · 2014Review
- Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros.Molecular medicine reports · 2014Article
- Expression of Nephrin Homologue in the Freshwater Planarian, Dugesia japonica.Acta histochemica et cytochemica · 2014Article
- Podocalyxin regulates pronephric glomerular development in zebrafish.Physiological reports · 2013Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Slit diaphragm (SD) is a highly specialized intercellular junction between podocyte foot processes and plays a crucial role in the formation of the filtration barrier. In this study, we examined the developmental localization of Nephrin, an essential component of SD, in the pronephric glomerulus of zebrafish and medaka. In the mature glomerulus of both fish, Nephrin is localized along the glomerular basement membrane as seen in mammals, indicating that Nephrin is localized at the SD. Interestingly, Nephrin was detected already in immature podocytes before the SD and foot processes started to form in both fish. Nephrin was localized along the cell surface of immature podocytes but as different localization patterns. In zebrafish, Nephrin signal bordered the lateral membrane of podocytes, which were columnar in shape, as in rat immature podocytes. However, in medaka immature podocytes, Nephrin was localized in a punctate pattern among podocyte cell bodies. These findings suggest that Nephrin needs to be integrated to the membrane before the formation of the SD and then moves to the proper site to form the SD. Furthermore, a podocyte-specific marker, such as Nephrin, should be a useful tool for the future analysis of pronephric glomerular development in fish mutants and morphants.
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