ArticleClinical and translational gastroenterology2012
Tissue-infiltrating lymphocytes analysis reveals large modifications of the duodenal "immunological niche" in coeliac disease after gluten-free diet.
Article in Clinical and translational gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Diet and psoriasis, part II: celiac disease and role of a gluten-free diet.Journal of the American Academy of Dermatology · 2014Pooled it
- Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease.Clinical and experimental immunology · 2015Trial
- Phenome of coeliac disease vs. inflammatory bowel disease.Scientific reports · 2022Article
- Single-cell approaches to dissect adaptive immune responses involved in autoimmunity: the case of celiac disease.Mucosal immunology · 2022Review
- Intestinal Regulatory T Cells.Advances in experimental medicine and biology · 2021Article
- Microtopography of Immune Cells in Osteoporosis and Bone Lesions by Endocrine Disruptors.Frontiers in immunology · 2020Review
- The Skin in Celiac Disease Patients: The Other Side of the Coin.Medicina (Kaunas, Lithuania) · 2019Review
- Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon.Frontiers in immunology · 2019Article
- Breg Cells in Celiac Disease Isolated or Associated to Hashimoto's Thyroiditis.International journal of endocrinology · 2018Article
- Digestive system in psoriasis: an update.Archives of dermatological research · 2017Review
- The Role of T-Cell Subsets in Chronic Inflammation in Celiac Disease and Inflammatory Bowel Disease Patients: More Common Mechanisms or More Differences?Inflammatory intestinal diseases · 2016Review
- Increased density of tolerogenic dendritic cells in the small bowel mucosa of celiac patients.World journal of gastroenterology · 2015Article
- The role of "bone immunological niche" for a new pathogenetic paradigm of osteoporosis.Analytical cellular pathology (Amsterdam) · 2015Review
- How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology.Journal of immunology research · 2015Review
- The Interaction among Microbiota, Immunity, and Genetic and Dietary Factors Is the Condicio Sine Qua Non Celiac Disease Can Develop.Journal of immunology research · 2015Review
- Uncomplicated diverticular disease: innate and adaptive immunity in human gut mucosa before and after rifaximin.Journal of immunology research · 2014Article
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Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe role of T lymphocytes in the pathogenesis of Celiac disease (CD) is well established. However, the mechanisms of T-cell involvement remain elusive. Little is known on the distribution of T subpopulations: T-regulatory (Treg), Th17, CD103, and CD62L cells at disease onset and after gluten-free diet (GFD). We investigated the involvement of several T subpopulations in the pathogenesis of CD.
methodsWe studied T cells both in the peripheral blood (PB) and the tissue-infiltrating lymphocytes (TILs) from the mucosa of 14 CD patients at presentation and after a GFD, vs. 12 controls.
resultsOur results extend the involvement of Treg, Th1, and Th17 cells in active CD inflammation both in the PB and at the TILs. At baseline, Tregs, Th1, and Th17 cells are significantly higher in active CD patients in TILs and PB. They decreased after diet. Moreover, CD62L+ TILs were increased at diagnosis as compared with GFD patients.
conclusionsOur data show significant modifications of the above-mentioned subpopulations both in the PB and TILs. The increase of suppressive Tregs in active CD both in the PB and TILs is intriguing. T lymphocytes are known to have a crucial role in the pathogenesis of CD. We have shown that gluten trigger results in systemic recruitment of T lymphocytes, the unbalance between pro-inflammatory and anti-inflammatory populations and the increase of CD62L+ T cells in TILs. Our results delineate a more complete picture of T-cell subsets in active vs. GFD disease. Our data of T-cell subpopulations, combined with known data on cytokine production, support the concept that duodenal micro-environment acts as an immunological niche and this recognition may have an important role in the diagnosis, prognosis and therapeutical approach of CD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.