ArticleRNA biology2013
Revisiting RNA-directed DNA methylation.
Article in RNA biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- Cross-kingdom RNAi: a universal mechanism of inter-organismal communication with many unknowns.Journal of experimental botany · 2026Review
- Exogenous 24nt siRNAs induce AGO4A-dependent silencing via promoter DNA methylation and H3K9me2 deposition.Frontiers in plant science · 2026Article
- Review
- Exogenous Application of dsRNA in Plant Protection: Efficiency, Safety Concerns and Risk Assessment.International journal of molecular sciences · 2024Review
- Epigenomics in stress tolerance of plants under the climate change.Molecular biology reports · 2023Review
- Review
- Epigenetic Modifications: An Unexplored Facet of Exogenous RNA Application in Plants.Plants (Basel, Switzerland) · 2020Article
- The ORF2 protein of Fusarium graminearum virus 1 suppresses the transcription of FgDICER2 and FgAGO1 to limit host antiviral defences.Molecular plant pathology · 2020Article
- Small RNA Mobility: Spread of RNA Silencing Effectors and its Effect on Developmental Processes and Stress Adaptation in Plants.International journal of molecular sciences · 2019Review
- The Rep proteins encoded by alphasatellites restore expression of a transcriptionally silenced green fluorescent protein transgene inVirusdisease · 2019Article
- Plant epigenetic mechanisms: role in abiotic stress and their generational heritability.3 Biotech · 2018Review
- Transgenerational stress-adaption: an opportunity for ecological epigenetics.Plant cell reports · 2018Review
- The RNA-induced transcriptional silencing complex targets chromatin exclusively via interacting with nascent transcripts.Genes & development · 2016Article
- Genome-wide identification of endogenous RNA-directed DNA methylation loci associated with abundant 21-nucleotide siRNAs in Arabidopsis.Scientific reports · 2016Article
- Long non-coding RNA produced by RNA polymerase V determines boundaries of heterochromatin.eLife · 2016Article
- Overexpression of the olive acyl carrier protein gene (OeACP1) produces alterations in fatty acid composition of tobacco leaves.Transgenic research · 2016Article
- Dicer-independent RNA-directed DNA methylation in Arabidopsis.Cell research · 2016Article
- Article
- A genome-wide identification of the miRNAome in response to salinity stress in date palm (Phoenix dactylifera L.).Frontiers in plant science · 2015Article
- Replicating Potato spindle tuber viroid mediates de novo methylation of an intronic viroid sequence but no cleavage of the corresponding pre-mRNA.RNA biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA-directed DNA methylation (RdDM) involves sequence-specific guiding of the de novo methylation machinery to complementary genomic DNA by RNA molecules. It is still elusive whether guide RNAs bind directly to DNA or to nascent transcripts produced from it. Even the nature of the guide RNAs is not elucidated. RNA interference (RNAi) studies provided a link between RNAi and RdDM indicating that small interfering RNAs (siRNAs) trigger and guide cytosine methylation. The "siRNA hypothesis" is generally accepted. However, recent data demonstrated that RdDM is not always associated with the accumulation of corresponding siRNAs. RdDM triggers may differ from guide RNAs and further studies are needed to clarify if guide RNAs are small or long RNAs, if they are single or double stranded and if they target DNA or nascent transcript.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.