ReviewNucleus (Austin, Tex.)
The CENP-A nucleosome: a battle between Dr Jekyll and Mr Hyde.
Review in Nucleus (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- High-resolution analysis of human centromeric chromatin.Life science alliance · 2025Article
- Proteomic Profiling of Extracellular Vesicles in Inflammatory Bowel Diseases.International journal of molecular sciences · 2025Article
- Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability.Molecular biology of the cell · 2023Article
- Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends.Nucleic acids research · 2020Article
- Five pillars of centromeric chromatin in fungal pathogens.PLoS pathogens · 2018Review
- Variants of core histones and their roles in cell fate decisions, development and cancer.Nature reviews. Molecular cell biology · 2017Review
- Internal modifications in the CENP-A nucleosome modulate centromeric dynamics.Epigenetics & chromatin · 2017Article
- Mass Spectrometry-Based Methodology for Identification of Native Histone Variant Modifications From Mammalian Tissues and Solid Tumors.Methods in enzymology · 2017Article
- Chromatin assembly: Journey to the CENter of the chromosome.The Journal of cell biology · 2016Review
- Replicating Nucleosomes.Science advances · 2015Article
- Review
- CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells.Epigenetics & chromatin · 2015Article
- Reply to "CENP-A octamers do not confer a reduction in nucleosome height by AFM".Nature structural & molecular biology · 2014Article
- CENP-A is essential for cardiac progenitor cell proliferation.Cell cycle (Georgetown, Tex.) · 2014Article
- CENP-A octamers do not confer a reduction in nucleosome height by AFM.Nature structural & molecular biology · 2014Article
- Centromeric heterochromatin: the primordial segregation machine.Annual review of genetics · 2014Review
- Tracking histone variant nucleosomes across the human cell cycle using biophysical, biochemical, and cytological analyses.Methods in molecular biology (Clifton, N.J.) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The structure of the centromere-specific histone centromeric protein A (CENP-A) nucleosome has been a hot topic of debate for the past five years. Structures proposed include octamers, hexamers, homotypic and heterotypic tetramers. This controversy has led to the proposal that CENP-A nucleosomes undergo cell-cycle dependent transitions between the multiple states previously documented to exist in vivo and in vitro. In recent work from our laboratory, we sought to test this hypothesis. We discovered that CENP-A nucleosomes undergo unique oscillations in human cells, a finding mirrored in a parallel study performed in budding yeast. This review provides additional insights into the potential mechanisms for the interconversion of CENP-A nucleosomal species, and speculates on a biological role for oscillations in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.