ArticleCell cycle (Georgetown, Tex.)2013
TIPE2 deficiency accelerates neointima formation by downregulating smooth muscle cell differentiation.
Article in Cell cycle (Georgetown, Tex.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Platelet membrane-modified exosomes targeting plaques to activate autophagy in vascular smooth muscle cells for atherosclerotic therapy.Drug delivery and translational research · 2025Article
- Dendritic cells transduced with TIPE-2 recombinant adenovirus induces T cells suppression.Journal of inflammation (London, England) · 2021Article
- Regulatory Roles of Tumor Necrosis Factor-α-Induced Protein 8 Like-Protein 2 in Inflammation, Immunity and Cancers: A Review.Cancer management and research · 2020Review
- Correlation of serum levels and gene expression of tumor necrosis factor-α-induced protein-8 like-2 with Parkinson disease severity.Metabolic brain disease · 2018Article
- TIPE Family of Proteins and Its Implications in Different Chronic Diseases.International journal of molecular sciences · 2018Review
- TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation.Oncology reports · 2018Article
- The decreased expression of TIPE2 protein in the decidua of patients with missed abortion and possible significance.Reproductive biology and endocrinology : RB&E · 2017Article
- TIPE3 protein promotes breast cancer metastasis through activating AKT and NF-κB signaling pathways.Oncotarget · 2017Article
- Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins.Cellular & molecular immunology · 2017Review
- Clinical Significance of TIPE2 Protein Upregulation in Non-Hodgkin's Lymphoma.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1/2 signaling.Cancer gene therapy · 2016Article
- The pro-apoptotic effects of TIPE2 on AA rat fibroblast-like synoviocytes via regulation of the DR5-caspase-NF-κB pathway in vitro.OncoTargets and therapy · 2016Article
- Identical expression profiling of human and murine TIPE3 protein reveals links to its functions.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
- Critical roles of TIPE2 protein in murine experimental colitis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- TIPE2 negatively regulates inflammation by switching arginine metabolism from nitric oxide synthase to arginase.PloS one · 2014Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenotypic switching of vascular smooth muscle cells (VSMCs) is known to play a key role in the development of atherosclerosis. However, the mechanisms that mediate VSMC phenotypic switching are unclear. We report here that TIPE2, the tumor necrosis factor (TNF) α-induced protein 8-like 2 (TNFAIP8L2), plays an atheroprotective role by regulating phenotypic switching of VSMCs in response to oxidized low-density lipoprotein (ox-LDL) stimuli. TIPE2-deficient VSMCs treated with ox-LDL expressed lower levels of contractile proteins such as SMαA, SM-MHC and calponin, whereas the proliferation, migration and the synthetic capacity for growth factors and cytokines were increased remarkably. Furthermore, TIPE2 inhibited VSMCs proliferation by preventing G 1/S phase transition. Interestingly, these effects of TIPE2 on VSMCs were dependent on P38 and ERK1/2 kinase signals. As a result, neointima formation was accelerated in the carotid arteries of TIPE2-deficient mice. These results indicate that TIPE2 is a potential inhibitor of atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.