ArticleBrain pathology (Zurich, Switzerland)2013
Multinodular and vacuolating neuronal tumors of the cerebrum: 10 cases of a distinctive seizure-associated lesion.
Article in Brain pathology (Zurich, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Multinodular and vacuolating neuronal tumor in the thalamus: case report and systematic review of literature.Acta neurochirurgica · 2024Pooled it
- cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading.Brain pathology (Zurich, Switzerland) · 2020Guideline
- Multinodular and vacuolating neuronal tumor: magnetic resonance imaging features.Acta neurologica Belgica · 2026Article
- A Child with Epileptic Seizure: A Case of Significantly Enhanced MVNT.Clinical neuroradiology · 2026Review
- A pathologically diagnosed multinodular and vacuolating neuronal tumor without typical multiple nodules: a case report.Frontiers in radiology · 2026Article
- The Benign Impostor: Recognizing a Multinodular and Vacuolating Neuronal Tumor to Prevent Unnecessary Intervention.Cureus · 2025Article
- The Mickey Mouse's hand sign in brain MRI points out multinodular and vacuolating neuronal tumors in mesial temporal lobe structures.Journal of neuro-oncology · 2025Article
- Multinodular and Vacuolating Neuronal Tumors: Imaging Features, Diagnosis, and Management Challenges.Diagnostics (Basel, Switzerland) · 2025Review
- Differentiation of multinodular and vacuolating neuronal tumor and dysembryoplastic neuroepithelial tumor based on MRI.Turkish journal of medical sciences · 2025Article
- Radiomics-driven neuro-fuzzy framework for rule generation to enhance explainability in MRI-based brain tumor segmentation.Frontiers in neuroinformatics · 2025Article
- Multinodular and vacuolating posterior fossa lesions of unknown significance: a long-term observational study and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Observational
- Multinodular Vacuolating Neuronal Tumors: Symptomatic Presentation Versus Incidental Finding: Case Series and Literature Review.Reports (MDPI) · 2024Article
- Vermian multinodular and vacuolating lesion of unknown significance discovered following syncope: a case report.Annals of medicine and surgery (2012) · 2024Article
- Extra-temporal pediatric low-grade gliomas and epilepsy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Imaging of pediatric glioneuronal and neuronal tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Multinodular and Vacuolating Neuronal Tumor-like Lesion of the Spinal Cord: Two Case Reports.AJNR. American journal of neuroradiology · 2024Article
- Multinodular and Vacuolating Neuronal Tumor Initially Misdiagnosed as Acute Cerebral Infarction Presenting With Thunderclap Headache.Journal of clinical neurology (Seoul, Korea) · 2024Article
- Long-term seizure outcome after epilepsy surgery of neuroglial tumors.Frontiers in neurology · 2024Article
- Long-term epilepsy associated-tumors (LEATs): what is new?Arquivos de neuro-psiquiatria · 2023Article
- Advanced multiparametric MRI and FDG-PET/CT in multinodular and vacuolating neuronal tumor: A pathologically confirmed case.Radiology case reports · 2023Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report 10 cases of a non-neurocytic, purely neuronal tumor affecting adults. Situated in the cerebral hemispheres, with 7 of 10 confined to the temporal lobes, most presented with seizures as their principal clinical manifestations. On magnetic resosnance imaging (MRI), the tumors generally appeared solid and non-contrast enhancing with minimal diffuse infiltration, edema, or mass effect. Six examples demonstrated internal nodularity. Microscopically, the tumor cells were largely distributed into discrete and coalescent nodules exhibiting varying degrees of matrix vacuolization, principally within the deep cortical ribbon and superficial subcortical white matter. Populating elements ranged from morphologically ambiguous to recognizably neuronal, with only two cases manifesting overt ganglion cell cytology. In all cases, tumor cells exhibited widespread nuclear immunolabeling for the HuC/HuD neuronal antigens, although expression of other neuronal markers, including synaptophysin, neurofilament and chromogranin was variable to absent. Tumor cells also failed to express GFAP, p53, IDH1 R132H, or CD34, although CD34-labeling ramified neural elements were present in the adjoining cortex of seven cases. Molecular analysis in a subset of cases failed to reveal DNA copy number abnormalities or BRAF V600E mutation. Follow-up data indicate that this unusual neuronal lesion behaves in benign, World Health Organization (WHO) grade I fashion and is amenable to surgical control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.