Evidence map›Paper›PMID 23323977›Full record

ReviewJournal of immunoassay & immunochemistry2013

Traditional biochemical assays for studying toll-like receptor 9.

Cynthia A Leifer, William A Rose, Fernando Botelho

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of immunoassay & immunochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cynthia A LeiferDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY, USA. cal59@cornell.edu
William A Rose
Fernando Botelho
Cornell University · US

Funding

Toll-like receptor 9: trafficking and signalingR01AI076588 · NIAID · CORNELL UNIVERSITY · PI LEIFER, CYNTHIA A · 2009 to 2013
$1.8M
Toll-like receptor 9 proteolytic processing and signalingR03AI097671 · NIAID · CORNELL UNIVERSITY · PI LEIFER, CYNTHIA A · 2012 to 2013
$154k
NIAID NIH HHS R01 AI076588NIAID NIH HHS R03 AI097671
6 · The paper itself

Abstract

Understanding the mechanistic basis of receptor activation and regulation can offer therapeutic targets for disease treatment. Evidence is emerging for a role of the normally foreign responsive Toll-like receptors (TLRs) in the development of autoimmunity through response to self-patterns. Regulatory mechanisms governing this class of receptors are poorly understood, and failures within this system likely contribute to development of autoimmunity. In this article, we review biochemical assays used to study one of the self-pattern responsive TLRs, TLR9, and suggest that these studies are critical for development of new targets for autoimmune therapies.

Indexed as

AnimalsCpG IslandsDNAGlycosylationHumansProtein Processing, Post-TranslationalRecombinant Fusion ProteinsToll-Like Receptor 9DNARecombinant Fusion ProteinsToll-Like Receptor 9

Identifiers

PMID23323977
PMCPMC4451183
OpenAlexW1977422721

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.