SynthesisHPB : the official journal of the International Hepato Pancreato Biliary Association2013
Surrogate endpoints in liver surgery related trials: a systematic review of the literature.
Synthesis in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Improving the quality of liver resection: a systematic review and critical analysis of the available prognostic models.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2015Pooled it
- Overview and recent trends of systematic reviews and meta-analyses in hepatology.Clinical and molecular hepatology · 2014Pooled it
- Extracellular NADCommunications biology · 2024Article
- Article
- Portal vein embolization in extended liver resection.Langenbeck's archives of surgery · 2017Review
- Users' guide to the surgical literature: how to assess an article using surrogate end points.Canadian journal of surgery. Journal canadien de chirurgie · 2017Article
- Validation of the peak bilirubin criterion for outcome after partial hepatectomy.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2016Article
- Selecting and measuring optimal outcomes for randomised controlled trials in surgery.Langenbeck's archives of surgery · 2014Review
- Endoscopic ulcers as a surrogate marker of NSAID-induced mucosal damage.Arthritis research & therapy · 2013Review
- Does ALT Correlate with Survival After Liver Resection for Colorectal Liver Metastases?Journal of clinical and experimental hepatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the safety of liver surgery has improved enormously, hepatic surgery continues to face challenging complications. Therefore, improvements supported by evidence-based guidelines are still required. The conduct of randomized controlled trials in liver surgery using dichotomous outcomes requires a large sample size. The use of surrogate endpoints (SEPs) reduces sample size but SEPs should be validated before use.
aimThe aim of this review was to summarize the SEPs used in hepatic surgery related trials, their definitions and recapitulating the evidence validating their use.
methodA systematic computerized literature search in the biomedical database PubMed using the MeSH terms 'hepatectomy' or 'liver resection' or 'liver transection' was conducted. Search was limited to papers written in the English language and published between 1 January 2000 and 1 January 2010.
resultsA total of 593 articles met the search terms and 49 articles were included in the final selection. Standard biochemical liver functions tests were the most frequently used SEP (32 of 49 the studies). The used definitions of SEPs varied greatly among the studies. Most studies referred to earlier published material to justify their choice of SEP. However, no validating studies were found.
conclusionMany SEPs are used in liver surgery trials however there is little evidence validating them.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.