ArticleTranslational oncology2012
Microscopic Delineation of Medulloblastoma Margins in a Transgenic Mouse Model Using a Topically Applied VEGFR-1 Probe.
Article in Translational oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Article
- Targeting Angiogenic Factors for the Treatment of Medulloblastoma.Current treatment options in oncology · 2022Review
- TRIPODD: a Novel Fluorescence Imaging Platform for In Situ Quantification of Drug Distribution and Therapeutic Response.Molecular imaging and biology · 2021Article
- Rapid pathology of lumpectomy margins with open-top light-sheet (OTLS) microscopy.Biomedical optics express · 2019Article
- SimultaneousClinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer.Molecular imaging and biology · 2016Article
- Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy.Scientific reports · 2016Article
- Ex vivo confocal microscopy imaging to identify tumor tissue on freshly removed brain sample.Journal of neuro-oncology · 2015Article
- Quantitative in vivo cell-surface receptor imaging in oncology: kinetic modeling and paired-agent principles from nuclear medicine and optical imaging.Physics in medicine and biology · 2015Review
- Quantification of the binding potential of cell-surface receptors in fresh excised specimens via dual-probe modeling of SERS nanoparticles.Scientific reports · 2015Article
- Trends in fluorescence image-guided surgery for gliomas.Neurosurgery · 2014Review
- Tumor endothelial marker imaging in melanomas using dual-tracer fluorescence molecular imaging.Molecular imaging and biology · 2014Article
- Accounting for pharmacokinetic differences in dual-tracer receptor density imaging.Physics in medicine and biology · 2014Article
- Comparison of Kinetic Models for Dual-Tracer Receptor Concentration Imaging in Tumors.Austin journal of biomedical engineering · 2014Article
- Mitigating fluorescence spectral overlap in wide-field endoscopic imaging.Journal of biomedical optics · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The unambiguous demarcation of tumor margins is critical at the final stages in the surgical treatment of brain tumors because patient outcomes have been shown to correlate with the extent of resection. Real-time high-resolution imaging with the aid of a tumor-targeting fluorescent contrast agent has the potential to enable intraoperative differentiation of tumor versus normal tissues with accuracy approaching the current gold standard of histopathology. In this study, a monoclonal antibody targeting the vascular endothelial growth factor receptor 1 (VEGFR-1) was conjugated to fluorophores and evaluated as a tumor contrast agent in a transgenic mouse model of medulloblastoma. The probe was administered topically, and its efficacy as an imaging agent was evaluated in vitro using flow cytometry, as well as ex vivo on fixed and fresh tissues through immunohistochemistry and dual-axis confocal microscopy, respectively. Results show a preferential binding to tumor versus normal tissue, suggesting that a topically applied VEGFR-1 probe can potentially be used with real-time intraoperative optical sectioning microscopy to guide brain tumor resections.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.