Trial reportThe Journal of clinical endocrinology and metabolism2013
Effects of estrogen with micronized progesterone on cortical and trabecular bone mass and microstructure in recently postmenopausal women.
Trial report in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Lessons from KEEPS: the Kronos Early Estrogen Prevention Study.Climacteric : the journal of the International Menopause Society · 2021Trial
- Effect of menopausal hormone therapy on proteins associated with senescence and inflammation.Physiological reports · 2020Trial
- Effects of Estrogen Replacement on Bone Geometry and Microarchitecture in Adolescent and Young Adult Oligoamenorrheic Athletes: A Randomized Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Trial
- Longitudinal effects of menopausal hormone treatments on platelet characteristics and cell-derived microvesicles.Platelets · 2016Trial
- Endothelial function in women of the Kronos Early Estrogen Prevention Study.Climacteric : the journal of the International Menopause Society · 2015Trial
- Menstrual status and bone health in athletes from different sports - a retrospective analysis.BMC sports science, medicine & rehabilitation · 2026Article
- Body Composition Attenuates the Association Between Serum 25-Hydroxyvitamin D and Bone Mineral Density in Early Postmenopausal Women.Nutrients · 2026Article
- The association between remnant cholesterol and the risk of osteoporotic vertebral fracture in older adults.PloS one · 2025Article
- Effectiveness and safety of hormone replacement therapy in the treatment of menopausal syndrome: a meta-analysis.American journal of translational research · 2025Review
- The Current Strategy in Hormonal and Non-Hormonal Therapies in Menopause-A Comprehensive Review.Life (Basel, Switzerland) · 2023Review
- Simulated effects of early menopausal bone mineral density preservation on long-term fracture risk: a feasibility study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Correlation Analysis of Adverse Reactions of Antiosteoporosis Drugs by Different Mechanisms with Bone Turnover and Vitamin D.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?Menopause (New York, N.Y.) · 2019Review
- Changes in carotid artery intima-media thickness 3 years after cessation of menopausal hormone therapy: follow-up from the Kronos Early Estrogen Prevention Study.Menopause (New York, N.Y.) · 2019Article
- Hip fractures in the elderly without osteoporosis.Journal of frailty, sarcopenia and falls · 2018Article
- An update on hormone therapy in postmenopausal women: mini-review for the basic scientist.American journal of physiology. Heart and circulatory physiology · 2017Review
- Changes in bone mineral density following long-term simultaneous pancreas-kidney transplantation.Journal of bone and mineral metabolism · 2016Article
- Fractures in Relation to Menstrual Status and Bone Parameters in Young Athletes.Medicine and science in sports and exercise · 2015Article
- Estimation of in vivo cortical bone thickness using ultrasonic waves.Journal of medical ultrasonics (2001) · 2015Article
- Congress on women's health Trudy Bush lecture 2014: new insights into sex Hormones and Cardiovascular disease.Journal of women's health (2002) · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
contextIn women, cortical bone mass decreases significantly at menopause. By contrast, loss of trabecular bone begins in the third decade and accelerates after menopause.
objectiveThe aim of the study was to investigate the effects of estrogen on cortical and trabecular bone.
designThe Kronos Early Estrogen Prevention Study is a double-blind, randomized, placebo-controlled trial of menopausal hormone treatment (MHT) in women, enrolled within 6-36 months of their final menstrual period.
settingThe study was conducted at the Mayo Clinic, Rochester, Minnesota.
interventionSubjects were treated with placebo (n = 31), or .45 mg/d conjugated equine estrogens (n = 20), or transdermal 50 μg/d 17β-estradiol (n = 25) with pulsed micronized progesterone.
main outcome measuresCortical and trabecular microarchitecture at the distal radius was assessed by high-resolution peripheral quantitative computed tomography.
resultsAt the distal radius, cortical volumetric bone mineral density (vBMD) decreased, and cortical porosity increased in the placebo group; MHT prevented these changes. By contrast, MHT did not prevent decreases in trabecular microarchitecture at the radius. However, MHT prevented decreases in trabecular vBMD at the thoracic spine (assessed in a subset of subjects; n = 51). These results indicate that MHT prevents deterioration in radial cortical vBMD and porosity in recently menopausal women.
conclusionThe maintenance of cortical bone in response to estrogen likely has important clinical implications because cortical bone morphology plays an important role in bone strength. However, effects of MHT on trabecular bone at the radius differ from those at the thoracic spine. Underlying mechanisms for these site-specific effects of MHT on cortical vs trabecular bone require further investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.