ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2013
Flexural properties of native and tissue-engineered human septal cartilage.
Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Tissue-Engineered Cartilage for Nasal Reconstruction: Mechanical Stimulation Through Bidirectional Bending.Annals of biomedical engineering · 2026Article
- Comparison of Mechanical Properties of Nasal Cartilage Preserved in Ethanol at 4 °C versus Normal Saline at -18 °C for Rhinoplasty Reuse.Iranian journal of otorhinolaryngology · 2026Article
- Human Septal Cartilage Tissue Engineering: Current Methodologies and Future Directions.Bioengineering (Basel, Switzerland) · 2024Review
- Evaluation of human nasal cartilage nonlinear and rate dependent mechanical properties.Journal of biomechanics · 2020Article
- Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine and compare the bending moduli of native and engineered human septal cartilage. STUDY
designProspective, basic science.
settingResearch laboratory. SUBJECTS AND
methodsNeocartilage constructs were fabricated from expanded human septal chondrocytes cultured in differentiation medium for 10 weeks. Constructs (n = 10) and native septal cartilage (n = 5) were tested in a 3-point bending apparatus, and the bending moduli were calculated using Euler-Bernoulli beam theory.
resultsAll samples were tested successfully and returned to their initial shape after unloading. The bending modulus of engineered constructs (0.32 ± 0.25 MPa, mean ± SD) was 16% of that of native septal cartilage (1.97 ± 1.25 MPa).
conclusionHuman septal constructs, fabricated from cultured human septal chondrocytes, are more compliant in bending than native human septal tissue. The bending modulus of engineered septal cartilage can be measured, and this modulus provides a useful measure of construct rigidity while undergoing maturation relative to native tissue.
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Registered trials
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