ArticleInvestigative ophthalmology & visual science2013
The retinal disease screening study: prospective comparison of nonmydriatic fundus photography and optical coherence tomography for detection of retinal irregularities.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Prevalence and risk factors of epiretinal membranes: a systematic review and meta-analysis of population-based studies.BMJ open · 2017Pooled it
- Evaluation of cystoid change phenotypes in ocular toxoplasmosis using optical coherence tomography.PloS one · 2014Trial
- Artificial intelligence method based on multi-feature fusion for automatic macular edema (ME) classification on spectral-domain optical coherence tomography (SD-OCT) images.Frontiers in neuroscience · 2023Article
- Total and horizontal distances of the foveal stereotaxic displacement can be prognostic indicators for patients with idiopathic epiretinal membrane.Frontiers in medicine · 2023Article
- Diagnostic accuracy of handheld fundus photography: A comparative study of three commercially available cameras.PLOS digital health · 2022Article
- Prospective evaluation of optical coherence tomography for disease detection in the Casey mobile eye clinic.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Secondary epiretinal membrane after Ex-Press glaucoma filtration device implant.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Optical Coherence Tomography Angiography Reveals Distinct Retinal Structural and Microvascular Abnormalities in Cerebrovascular Disease.Frontiers in neuroscience · 2020Article
- Evaluation of a Remote Diagnosis Imaging Model vs Dilated Eye Examination in Referable Macular Degeneration.JAMA ophthalmology · 2019Article
- Role of advanced technology in the detection of sight-threatening eye disease in a UK community setting.BMJ open ophthalmology · 2019Article
- Detection of Age-Related Macular Degeneration by Portable Optical Coherence Tomography Operated by Nonexpert Personnel: Potential Use for Screenings.Journal of vitreoretinal diseases · 2019Article
- Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography.PloS one · 2015Article
- An easy method to differentiate retinal arteries from veins by spectral domain optical coherence tomography: retrospective, observational case series.BMC ophthalmology · 2014Observational
- Incidence of Referable Retinal Disease in Diabetic Patients at a Primary Care Practice.Journal of vitreoretinal diseasesArticle
- Utility of multimodal imaging in the clinical diagnosis of inherited retinal degenerations.Taiwan journal of ophthalmologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo compare the sensitivity of volume scanning with optical coherence tomography (OCT) to nonmydriatic color fundus photography (FP) for the detection of retinal irregularities in asymptomatic populations.
methodsAsymptomatic subjects without known ocular disease were recruited over a 6-month period. For each eye, two undilated 45° fundus images and four undilated volume OCT image sets covering the macula and optic nerve were obtained. Color images were evaluated for irregularities both inside and outside the area covered by OCT. OCT image sets were evaluated for internal limiting membrane irregularities, abnormal retinal thickness, hyper/hyporeflective features, and photoreceptor/retinal pigment epithelium (RPE) irregularities. Detection sensitivities were compared and false-negative cases were analyzed.
resultsA total of 284 eyes (144 subjects) were included, with a mean age of 38.1 years (range 18-77). Among 253 eyes (135 subjects) with gradable images from both FP and OCTs, the detection sensitivities for OCT were higher (96.2% infield and 85.7% in full field) than for FP (19.9% infield and 43.8% in full field) for all irregularities evaluated in the study (including epiretinal irregularities, abnormal retinal thickness, intraretinal hyperreflective/hyporeflective features, and photoreceptor/RPE irregularities). Overall, the presence of definite irregularities on either fundus imaging or OCT by eye in this asymptomatic population was 42.6% (121/284), with 39.4% (112/284) of eyes having RPE irregularities such as drusen.
conclusionsFor detection of a variety of retinal irregularities evaluated in the current study, volume OCT scanning was more sensitive than nonmydriatic retinal photography in our asymptomatic individuals. OCT detected clinically relevant disease features, such as subretinal fluid, that were missed by FP, and had a lower ungradable image rate. It is likely that OCT will be added to photography screening in the near future for chorioretinal disease.
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