Evidence map›Paper›PMID 23322525›Full record

ArticleMedical oncology (Northwood, London, England)2013

BAG-1 expression in human meningioma and correlation with clinical characteristics.

Kaiyu Zhou, Hanghuang Jin, Ting Zhou, Yongkang Luo

Abstract read
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In one paragraph

Article in Medical oncology (Northwood, London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kaiyu ZhouDepartment of Neurosurgery, Taizhou Municipal Hospital, Taizhou Medical College, Taizhou 318000, China. kerry2000year@163.com
Hanghuang Jin
Ting Zhou
Yongkang Luo
Taizhou Municipal Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to investigate BAG-1 expression in human meningiomas and to assess its association with pathological and clinical characteristics. BAG-1 expression was analyzed in 158 specimens of meningiomas using immunohistochemical staining, and the results were graded according to the positivity ratio and the staining intensity. We examined the correlations between BAG-1 expression and the 2007 WHO pathological classification, peritumoral edema and postoperative recurrence. There were no significant differences in BAG-1 expression among meningioma subtypes within the same histopathologic grade, as well as between grades II and III. BAG-1 expression in grade I was much higher than in grade II (P < 0.05) or III (P < 0.01). BAG-1 expression was gradually decreased with increasing WHO pathologic classification (χ (2) = 141.49, P < 0.01), as well as with the increase in peritumoral edema (χ (2) = 43.93, P < 0.01) and postoperative recurrence (χ (2) = 55.13, P < 0.01). BAG-1 expression in meningioma depends upon WHO pathologic classification and is decreased in higher tumor classification. It is associated with heavier peritumoral edema and more postoperative recurrences.

Indexed as

AdolescentAdultAgedBiomarkers, TumorDNA-Binding ProteinsEdemaFemaleHumansImmunohistochemistryMaleMeningeal NeoplasmsMeningiomaMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalTranscription FactorsBCL2-associated athanogene 1 proteinBiomarkers, TumorDNA-Binding ProteinsTranscription Factors

Identifiers

PMID23322525
OpenAlexW2142678577

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.