Evidence map›Paper›PMID 23322458›Full record

ArticleThe Journal of rheumatology2013

Cost-related medication nonadherence in older patients with rheumatoid arthritis.

Leslie R Harrold, Becky A Briesacher, Dan Peterson, Ashley Beard, Jeanne Madden, Fang Zhang, Jerry H Gurwitz, Stephen B Soumerai

Abstract readComparative Study
In one paragraph

Article in The Journal of rheumatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Leslie R HarroldMeyers Primary Care Institute, and the University of Massachusetts Medical School, Department of Medicine, Worcester, MA 01605, USA. Leslie.Harrold@umassmed.edu
Becky A Briesacher
Dan Peterson
Ashley Beard
Jeanne Madden
Fang Zhang
Jerry H Gurwitz
Stephen B Soumerai

Funding

Impact of Medicare Drug Benefit on Use and Cost-related Underuse of MedicinesR01AG028745 · NIA · HARVARD PILGRIM HEALTH CARE, INC. · PI SOUMERAI, STEPHEN B · 2006 to 2014
$3.2M
Cost-Related Underuse of Medications in the ElderlyR01AG022362 · NIA · HARVARD PILGRIM HEALTH CARE, INC. · PI SOUMERAI, STEPHEN B · 2003 to 2006
$1.3M
Cost-related Underuse of Medications and the Health of Older AdultsK01AG031836 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BRIESACHER, BECKY A · 2008 to 2012
$679k
Assessing and Improving Arthritis Medication Adherence: Gout as a ModelK23AR053856 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HARROLD, LESLIE R · 2007 to 2011
$641k
NIAMS NIH HHS K23 AR053856NIAMS NIH HHS K23AR053856NIA NIH HHS K01 AG031836NIA NIH HHS K01AG031836NIA NIH HHS R01 AG022362NIA NIH HHS R01AG022362NIA NIH HHS R01 AG028745NIA NIH HHS R01AG028745
6 · The paper itself

Abstract

objectiveEconomic access to costly medications including biologic agents can be challenging. Our objective was to examine whether patients with rheumatoid arthritis (RA) are at particular risk for cost-related medication nonadherence (CRN) and spending less on basic needs.

methodsWe identified a nationally representative sample of older adults with RA (n = 1100) in the Medicare Current Beneficiary Survey (2004-2008) and compared them to older adults with other morbidities categorized by chronic disease count: 0 (n = 5898), 1-2 (n = 30,538), and ≥ 3 (n = 34,837). We compared annual rates of self-reported CRN (skipping or reducing medication doses or not obtaining prescriptions because of cost) as well as spending less on basic needs to afford medications and tested for differences using survey-weighted logistic regression analyses adjusted for demographic characteristics, health status, and prescription drug coverage.

resultsIn the RA sample, the unadjusted weighted prevalence of CRN ranged from 20.7% in 2004 to 18.4% in 2008 as compared to 18.5% and 11.9%, respectively, in patients with 3 or more non-RA conditions. In adjusted analyses, having RA was associated with a 3.5-fold increase in the risk of CRN (OR 3.52, 95% CI 2.63-4.71) and almost a 2.5-fold risk of spending less on basic needs (OR 2.41, 95% CI 1.78-3.25) as compared to those without a chronic condition.

conclusionPatients with RA experience a high prevalence of CRN and forgoing of basic needs, more than do older adults with multiple other chronic conditions. The situation did not improve during a period of policy change aimed at alleviating high drug costs.

Indexed as

Drug MonitoringAgedAged, 80 and overAntirheumatic AgentsArthritis, RheumatoidDrug CostsFemaleHealth SurveysHumansIncomeInsurance, Pharmaceutical ServicesMaleMedicareMiddle AgedPrescription DrugsPrevalenceAntirheumatic AgentsPrescription Drugs

Identifiers

PMID23322458
PMCPMC3815617

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.