ArticleGenes & development2013
Homologous recombination as a mechanism to recognize repetitive DNA sequences in an RNAi pathway.
Article in Genes & development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Tandem repeat-induced sexual silencing: A Rid-dependent RNAi mechanism for fungal genome defense via translational repression.Science advances · 2025Article
- Remodeling of perturbed chromatin can initiate de novo transcriptional and post-transcriptional silencing.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Functions of RNAi Pathways in Ribosomal RNA Regulation.Non-coding RNA · 2024Review
- An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans.Developmental cell · 2021Article
- Disruption of a ∼23-24 nucleotide small RNA pathway elevates DNA damage responses inMolecular biology of the cell · 2021Article
- Copy number-dependent DNA methylation of the Pyricularia oryzae MAGGY retrotransposon is triggered by DNA damage.Communications biology · 2021Article
- Establishment of Neurospora crassa as a model organism for fungal virology.Nature communications · 2020Article
- Conserved chromosomal functions of RNA interference.Nature reviews. Genetics · 2020Review
- RNA-induced initiation of transcriptional silencing (RITS) complex structure and function.RNA biology · 2019Review
- A DNA repair protein and histone methyltransferase interact to promote genome stability in the Caenorhabditis elegans germ line.PLoS genetics · 2019Article
- From "Cellular" RNA to "Smart" RNA: Multiple Roles of RNA in Genome Stability and Beyond.Chemical reviews · 2018Review
- DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition.Molecular cell · 2017Article
- Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks.PLoS genetics · 2017Article
- RNA interference is essential for cellular quiescence.Science (New York, N.Y.) · 2016Article
- Nuclear Noncoding RNAs and Genome Stability.Molecular cell · 2016Review
- Mechanism of siRNA production from repetitive DNA.Genes & development · 2015Article
- Efficient detection of unpaired DNA requires a member of the rad54-like family of homologous recombination proteins.Genetics · 2014Article
- Article
- Histone H3K56 acetylation is required for quelling-induced small RNA production through its role in homologous recombination.The Journal of biological chemistry · 2014Article
- Recognizing the enemy within: licensing RNA-guided genome defense.Trends in biochemical sciences · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
Quelling is an RNAi-related phenomenon that post-transcriptionally silences repetitive DNA and transposons in Neurospora. We previously identified a type of DNA damage-induced small RNA called qiRNA that originates from ribosomal DNA. To understand how small RNAs are generated from repetitive DNA, we carried out a genetic screen to identify genes required for qiRNA biogenesis. Factors directly involved in homologous recombination (HR) and chromatin remodeling factors required for HR are essential for qiRNA production. HR is also required for quelling, and quelling is also the result of DNA damage, indicating that quelling and qiRNA production share a common mechanism. Together, our results suggest that DNA damage-triggered HR-based recombination allows the RNAi pathway to recognize repetitive DNA to produce small RNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.