ArticleBritish journal of cancer2013
Use of statins and risk of glioma: a nationwide case-control study in Denmark.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Pooled it
- Do statins, ACE inhibitors or sartans improve outcome in primary glioblastoma?Journal of neuro-oncology · 2018Trial
- Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape.Signal transduction and targeted therapy · 2023Article
- Therapeutic Potential of Nanomedicine in Management of Alzheimer's Disease and Glioma.International journal of nanomedicine · 2023Review
- Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism.Cancers · 2022Article
- Cholesterol metabolism and its implication in glioblastoma therapy.Journal of Cancer · 2022Review
- Role of macrophage in nanomedicine-based disease treatment.Drug delivery · 2021Review
- Phenotypic screening system using three-dimensional (3D) culture models for natural product screening.The Journal of antibiotics · 2021Review
- Risk factors for childhood and adult primary brain tumors.Neuro-oncology · 2019Review
- Statin use, hyperlipidemia, and risk of glioma.European journal of epidemiology · 2019 · on this mapArticle
- Statins and the Brain: More than Lipid Lowering Agents?Current neuropharmacology · 2019Review
- Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells.BioMed research international · 2019Article
- Drug Repurposing of Metabolic Agents in Malignant Glioma.International journal of molecular sciences · 2018Review
- The role of atorvastatin in suppressing tumor growth of uterine fibroids.Journal of translational medicine · 2018Article
- Confounding in observational studies based on large health care databases: problems and potential solutions - a primer for the clinician.Clinical epidemiology · 2017Article
- Reply to Comment on 'Statin use and all-cancer survival: prospective results from the Women's Health Initiative'.British journal of cancer · 2017Article
- Reply to Greenland: A serious misinterpretation of a consistent inverse association of statin use with glioma across 3 case-control studies.European journal of epidemiology · 2017Article
- A serious misinterpretation of a consistent inverse association of statin use with glioma across 3 case-control studies.European journal of epidemiology · 2017Article
- Protective Effects of Statins in Cancer: Should They Be Prescribed for High-Risk Patients?Current atherosclerosis reports · 2016Review
- Statin use and risk of glioma: population-based case-control analysis.European journal of epidemiology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLaboratory studies and a single case-control study have suggested a protective effect of statins on the risk of glioma. We wished to investigate the influence of statin use on the risk of glioma in a population-based setting.
methodsWe conducted a nationwide case-control study in Denmark based on population-based medical registries. We identified all patients aged 20 to 85 years with a first diagnosis of histologically verified glioma during 2000-2009. These cases were matched on birth year and sex with population controls. Prior use of statins since 1995 was classified into short-term use (<5 years) and long-term use (5+ years). We used conditional logistic regression to compute odds ratios (ORs), with 95% confidence intervals (CIs), for glioma associated with statin use, adjusted for potential confounders.
resultsA total of 2656 cases and 18,480 controls were included in the study. The risk of glioma was reduced among long-term statin users (OR=0.76; 95% CI: 0.59-0.98) compared with never users of statins, and was inversely related to the intensity of statin treatment among users (OR=0.71; 95% CI: 0.44-1.15 for highest intensity). The inverse association between long-term statin treatment and glioma risk was more pronounced among men aged ≤ 60 years (OR=0.40; 95% CI: 0.17-0.91) compared with men aged 60+ years (OR=0.71; 95% CI: 0.49-1.03). An inverse association was also observed among women aged ≤ 60 years (OR=0.28; 95% CI: 0.06-1.25), but not among women over age 60 years (OR=1.23; 95% CI: 0.82-1.85).
conclusionLong-term statin use may reduce the risk of glioma.
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