Evidence map›Paper›PMID 23322102›Full record

ReviewSensors (Basel, Switzerland)2013

Monitoring ion activities in and around cells using ion-selective liquid-membrane microelectrodes.

Seong-Ki Lee, Walter F Boron, Mark D Parker

Abstract readReview
In one paragraph

Review in Sensors (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. NHFrontiers in physiology · 2024
    Article
  4. Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Simultaneous Monitoring of pH and Chloride (ClInternational journal of molecular sciences · 2021
    Article
  9. Review
  10. pH dependence of the Slc4a11-mediated HAmerican journal of physiology. Cell physiology · 2020
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Seong-Ki LeeDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. sxl271@case.edu
Walter F Boron
Mark D Parker

Funding

PH REGULATION OF EXCITABLE INVERTEBRATE CELLSR01NS018400 · NINDS · YALE UNIVERSITY · PI BORON, WALTER F · 1985 to 2012
$5.1M
Physiology of Electrogenic Na/HCO3 CotransportersR37DK030344 · NIDDK · YALE UNIVERSITY · PI BORON, WALTER F · 2002 to 2011
$3.5M
REGULATION OF INTRACELLULAR PH IN RENAL PROXIMAL TUBULER01DK030344 · NIDDK · YALE UNIVERSITY · PI BORON, WALTER F. · 1986 to 2001
$660k
Functional role of transporter Slc4a11 (BTR1/NaBC1) in the corneaR21EY021646 · NEI · UNIV OF ARKANSAS FOR MED SCIS · PI JENNINGS, MICHAEL L, PARKER, MARK · 2012 to 2013
$416k
NEI NIH HHS EY021646NEI NIH HHS R21 EY021646NIDDK NIH HHS DK30344NIDDK NIH HHS R01 DK030344NIDDK NIH HHS R37 DK030344NINDS NIH HHS NS18400NINDS NIH HHS R01 NS018400
6 · The paper itself

Abstract

Determining the effective concentration (i.e., activity) of ions in and around living cells is important to our understanding of the contribution of those ions to cellular function. Moreover, monitoring changes in ion activities in and around cells is informative about the actions of the transporters and/or channels operating in the cell membrane. The activity of an ion can be measured using a glass microelectrode that includes in its tip a liquid-membrane doped with an ion-selective ionophore. Because these electrodes can be fabricated with tip diameters that are less than 1 μm, they can be used to impale single cells in order to monitor the activities of intracellular ions. This review summarizes the history, theory, and practice of ion-selective microelectrode use and brings together a number of classic and recent examples of their usefulness in the realm of physiological study.

Indexed as

Ion-Selective ElectrodesAnimalsCalibrationCell MembraneIonophoresIonsMicroelectrodesIonophoresIons

Identifiers

PMID23322102
PMCPMC3574717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.