ArticleJournal of exposure science & environmental epidemiology
Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress.
Article in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 86 citations in OpenAlex.
- The effects of facemasks on airway inflammation and endothelial dysfunction in healthy young adults: a double-blind, randomized, controlled crossover study.Particle and fibre toxicology · 2018Trial
- A controlled trial of acute effects of human exposure to traffic particles on pulmonary oxidative stress and heart rate variability.Particle and fibre toxicology · 2014Trial
- Mega-Events, Air Pollution and Health Outcomes: A Systematic Review.Antioxidants (Basel, Switzerland) · 2026Review
- Prenatal air pollution exposure and placental vasculature development among participants of the UPSIDE cohort study.Environmental research · 2025Article
- Systemic oxidative stress levels during the course of pregnancy: Associations with exposure to air pollutants.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Metal and oxidative potential exposure through particle inhalation and oxidative stress biomarkers: a 2-week pilot prospective study among Parisian subway workers.International archives of occupational and environmental health · 2024Article
- Indoor (residential) and ambient particulate matter associations with urinary oxidative stress biomarkers in a COPD cohort.The Science of the total environment · 2023Article
- Pulmonary, inflammatory, and oxidative effects of indoor nitrogen dioxide in patients with COPD.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- The Impact of Metformin on Dust-Induced Histopathological Changes and Oxidative Stress in the Liver: An Insight into Dust Concentration and Liver Biomarkers in Animal Models.Reports of biochemistry & molecular biology · 2023Article
- Lipid Peroxidation Produces a Diverse Mixture of Saturated and Unsaturated Aldehydes in Exhaled Breath That Can Serve as Biomarkers of Lung Cancer-A Review.Metabolites · 2022Review
- Review
- A Biomonitoring Pilot Study in Workers from a Paints Production Plant Exposed to Pigment-Grade Titanium Dioxide (TiOToxics · 2022Article
- Review
- Interstitial Lung Diseases and Air Pollution: Narrative Review of Literature.Pulmonary therapy · 2021Review
- Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years.Nanomaterials (Basel, Switzerland) · 2020Article
- Environmental risk factors and their footprints in vivo - A proposal for the classification of oxidative stress biomarkers.Redox biology · 2020Review
- LC-MS Quantification of Malondialdehyde-Dansylhydrazine Derivatives in Urine and Serum Samples.Journal of analytical toxicology · 2020Article
- Chemical Biomarkers of Exposure and Early Damage from Potentially Carcinogenic Airborne Pollutants.Annals of cancer epidemiology · 2019Article
- Urinary mutagenicity and other biomarkers of occupational smoke exposure of wildland firefighters and oxidative stress.Inhalation toxicology · 2019Article
- Quantification of malondialdehyde in exhaled breath condensate using pseudo two-dimensional ultra-performance liquid chromatography coupled with single quadrupole mass spectrometry.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2019Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
Underlying mechanisms by which air pollutants adversely affect human health remain poorly understood. Oxidative stress has been considered as a potential mechanism that may promote lipid peroxidation by reactive oxygen species, leading to the formation of malondialdehyde (MDA) that is excreted in biofluids (e.g., urine and exhaled breath condensate (EBC)). A panel study was conducted to examine whether concentrations of MDA in EBC and urine were associated, respectively, with changes in air pollution levels brought by the Beijing Olympic air pollution control measures. EBC and urine samples from 125 healthy adults were collected twice in each of the pre-, during-, and post-Olympic periods. Period-specific means of MDA and changes in MDA levels associated with increases in 24-h average pollutant concentrations were estimated using linear mixed-effects models. From the pre- to the during-Olympic period, when concentrations of most pollutants decreased, EBC MDA and urinary MDA significantly decreased by 24% (P<0.0001) and 28% (P=0.0002), respectively. From the during-Olympic to the post-Olympic period, when concentrations of most pollutants increased, EBC MDA and urinary MDA increased by 28% (P=0.094) and 55% (P=0.046), respectively. Furthermore, the largest increases in EBC MDA associated with one interquartile range (IQR) increases in all pollutants but ozone ranged from 10% (95% CI: 2%, 18%) to 19% (95% CI: 14%, 25%). The largest increases in urinary MDA associated with IQR increases in pollutant concentration ranged from 9% (95%: 0.3%, 19%) to 15% (95% CI: 3%, 28%). These findings support the utility of EBC MDA as a biomarker of oxidative stress in the respiratory tract and urinary MDA as a biomarker of systemic oxidative stress in relation to air pollution exposure in healthy young adults. Both EBC and urine samples can be collected noninvasively in the general population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.