ArticleJournal of exposure science & environmental epidemiology2013
Longitudinal assessment of chlorpyrifos exposure and effect biomarkers in adolescent Egyptian agricultural workers.
Article in Journal of exposure science & environmental epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Association of pesticide exposure with neurobehavioral outcomes among avocado farmworkers in Mexico.International journal of hygiene and environmental health · 2024Article
- Evaluating how occupational exposure to organophosphates and pyrethroids impacts ADHD severity in Egyptian male adolescents.Neurotoxicology · 2023Article
- The association between organophosphate insecticides and blood pressure dysregulation: NHANES 2013-2014.Environmental health : a global access science source · 2022Article
- Concurrent urinary organophosphate metabolites and acetylcholinesterase activity in Ecuadorian adolescents.Environmental research · 2022Article
- Time after a peak-pesticide use period and neurobehavior among ecuadorian children and adolescents: The ESPINA study.Environmental research · 2022Article
- Impact of Micronutrient Supplementation on Pesticide Residual, Acetylcholinesterase Activity, and Oxidative Stress Among Farm Children Exposed to Pesticides.Frontiers in public health · 2022Article
- Article
- Evaluation of occupational pesticide exposure on Egyptian male adolescent cognitive and motor functioning.Environmental research · 2021Article
- Magnitude of behavioral deficits varies with job-related chlorpyrifos exposure levels among Egyptian pesticide workers.Neurotoxicology · 2020Article
- Occupational pesticide exposure and symptoms of attention deficit hyperactivity disorder in adolescent pesticide applicators in Egypt.Neurotoxicology · 2019Article
- Associations of acetylcholinesterase activity with depression and anxiety symptoms among adolescents growing up near pesticide spray sites.International journal of hygiene and environmental health · 2019Article
- Blood pressure after a heightened pesticide spray period among children living in agricultural communities in Ecuador.Environmental research · 2019Article
- Respiratory Condition of Family Farmers Exposed to Pesticides in the State of Rio de Janeiro, Brazil.International journal of environmental research and public health · 2018Article
- Acetylcholinesterase activity and time after a peak pesticide-use period among Ecuadorian children.International archives of occupational and environmental health · 2018Article
- Longitudinal assessment of occupational determinants of chlorpyrifos exposure in adolescent pesticide workers in Egypt.International journal of hygiene and environmental health · 2017Article
- Potential short-term neurobehavioral alterations in children associated with a peak pesticide spray season: The Mother's Day flower harvest in Ecuador.Neurotoxicology · 2017Article
- Pesticide exposure and subjective symptoms of cut-flower farmers.Journal of rural medicine : JRM · 2017Review
- Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt.PloS one · 2017Article
- The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators.Journal of toxicology and environmental health. Part A · 2017Article
- Phenobarbital use and neurological problems in FMR1 premutation carriers.Neurotoxicology · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Chlorpyrifos (CPF) is applied seasonally in Egypt by adolescent agricultural workers and the extent of occupational exposure and the potential for environmental CPF exposure in this population is poorly understood. Adolescent pesticide applicators (n=57; 12-21 years of age) and age-matched non-applicators (n=38) from the same villages were followed for 10 months in 2010, spanning pre-application through post-application. Eight urine and five blood samples were collected from participants within this time period. Blood acetylcholinesterase and butyrylcholinesterase (BChE; exposure/effect biomarker) and urine 3,5,6-trichloro-2-pyridinol (TCPy; exposure biomarker) were used to assess occupational CPF exposures in pesticide applicators and environmental exposures in non-applicators. Applicators demonstrated significantly higher TCPy concentration and BChE depression than non-applicators throughout CPF application. This difference persisted for 4-7 weeks after the cessation of agricultural spraying. However, both groups exhibited significantly elevated TCPy and depressed BChE, compared with their respective baseline. The peak TCPy levels during the spray season (95% confidence interval (CI)) for non-applicators and applicators reached 16.8 (9.87-28.5) and 137 (57.4-329) ug/g creatinine, respectively. BChE levels (95% CIs) during the spray were as follows: 1.47 (1.28-1.68) for non-applicators and 0.47 (0.24-0.94) U/ml for applicators. The longitudinal assessment of CPF biomarkers provided robust measures of exposure and effect throughout CPF application in adolescents and revealed significant exposures in both applicators and non-applicators. Biomarker data in the non-applicators, which mirrored that of the applicators, indicated that non-applicators received environmental CPF exposures. This suggests that similar exposures may occur in other residents of this region during periods of pesticide application.
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