ArticleTranslational psychiatry2013
RNAi-mediated serotonin transporter suppression rapidly increases serotonergic neurotransmission and hippocampal neurogenesis.
Article in Translational psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Dynamic changes of serotonin transporter expression in the prefrontal cortex evoked by aggressive social interactions.Neurobiology of stress · 2025Article
- mTOR Knockdown in the Infralimbic Cortex Evokes A Depressive-like State in Mouse.International journal of molecular sciences · 2021Article
- Review
- Effect of pharmacological manipulations on Arc function.Current research in pharmacology and drug discovery · 2021Review
- The Role of Astrocytes in the Neurorepair Process.Frontiers in cell and developmental biology · 2021Article
- Article
- β-Catenin Role in the Vulnerability/Resilience to Stress-Related Disorders Is Associated to Changes in the Serotonergic System.Molecular neurobiology · 2020Article
- Selective Knockdown of TASK3 Potassium Channel in Monoamine Neurons: a New Therapeutic Approach for Depression.Molecular neurobiology · 2019Article
- Hypersensitivity to sertraline in the absence of hippocampal 5-HTEnvironmental epigenetics · 2018Article
- Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis.International journal of molecular sciences · 2017Review
- Response of Htr3a knockout mice to antidepressant treatment and chronic stress.British journal of pharmacology · 2017Article
- Novel 5-HTPsychopharmacology · 2017Article
- Glial GLT-1 blockade in infralimbic cortex as a new strategy to evoke rapid antidepressant-like effects in rats.Translational psychiatry · 2017Article
- Divergent Roles of Central Serotonin in Adult Hippocampal Neurogenesis.Frontiers in cellular neuroscience · 2017Review
- Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin.European archives of psychiatry and clinical neuroscience · 2016Article
- Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior.Brain, behavior, and immunity · 2016Article
- Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration.Molecular psychiatry · 2016Article
- A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression.Frontiers in neuroscience · 2015Review
- Targeting intestinal inflammation with CD98 siRNA/PEI-loaded nanoparticles.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Neural plasticity and proliferation in the generation of antidepressant effects: hippocampal implication.Neural plasticity · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current antidepressants, which inhibit the serotonin transporter (SERT), display limited efficacy and slow onset of action. Here, we show that partial reduction of SERT expression by small interference RNA (SERT-siRNA) decreased immobility in the tail suspension test, displaying an antidepressant potential. Moreover, short-term SERT-siRNA treatment modified mouse brain variables considered to be key markers of antidepressant action: reduced expression and function of 5-HT(1A)-autoreceptors, elevated extracellular serotonin in forebrain and increased neurogenesis and expression of plasticity-related genes (BDNF, VEGF, Arc) in hippocampus. Remarkably, these effects occurred much earlier and were of greater magnitude than those evoked by long-term fluoxetine treatment. These findings highlight the critical role of SERT in serotonergic function and show that the reduction of SERT expression regulates serotonergic neurotransmission more potently than pharmacological blockade of SERT. The use of siRNA-targeting genes in serotonin neurons (SERT, 5-HT(1A)-autoreceptor) may be a novel therapeutic strategy to develop fast-acting antidepressants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.