ReviewMolecular neurobiology2013
Alternatively activated macrophages in spinal cord injury and remission: another mechanism for repair?
Review in Molecular neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Regulatory effect of inflammatory mediators in spinal cord injury.Frontiers in immunology · 2025Review
- A Novel Acute Discogenic Myelopathy Model Using MerocelKorean journal of neurotrauma · 2023Article
- Progression in translational research on spinal cord injury based on microenvironment imbalance.Bone research · 2022Review
- Article
- Alendronate Enhances Functional Recovery after Spinal Cord Injury.Experimental neurobiology · 2022Article
- Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration.Journal of neuroinflammation · 2021Review
- Ninjurin-1: a biomarker for reflecting the process of neuroinflammation after spinal cord injury.Neural regeneration research · 2021Article
- Targeted Delivery of Mesenchymal Stem Cell-Derived Nanovesicles for Spinal Cord Injury Treatment.International journal of molecular sciences · 2020Article
- Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy.Cell death & disease · 2019Article
- Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration.International journal of molecular medicine · 2018Article
- Mesenchymal Stem Cell-Macrophage Choreography Supporting Spinal Cord Repair.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury.Journal of neuroinflammation · 2018Article
- Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3β and activating heme oxygenase-1.Anatomy & cell biology · 2017Article
- Lentiviral-Mediated Netrin-1 Overexpression Improves Motor and Sensory Functions in SCT Rats Associated with SYP and GAP-43 Expressions.Molecular neurobiology · 2017Article
- Effects of different fluences of low-level laser therapy in an experimental model of spinal cord injury in rats.Lasers in medical science · 2017Article
- Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines.Journal of neuroinflammation · 2016Article
- Macrophage polarization in nerve injury: do Schwann cells play a role?Neural regeneration research · 2016Review
- Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury.Experimental neurology · 2015Article
- Local Injection of Lenti-BDNF at the Lesion Site Promotes M2 Macrophage Polarization and Inhibits Inflammatory Response After Spinal Cord Injury in Mice.Cellular and molecular neurobiology · 2015Article
- Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury.Journal of neuroinflammation · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissues within the central nervous system (CNS) have generally been regarded as immunologically privileged. However, in recent decades, it has been shown that immune reactions in the CNS continuously occur via various types of inflammation following autoimmune diseases and mechanical insults such as spinal cord injury (SCI). Among the various inflammatory cells associated with CNS disease, activated macrophages are classically known to induce detrimental consequences that are mediated by the secretion of pro-inflammatory molecules. Alternatively activated macrophages have recently been shown to modulate various types of CNS inflammation, including SCI. This review summarizes the potential roles of alternatively activated macrophages in the course of CNS inflammation in rodent SCI models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.