ArticleHeredity2013
Gene flow and gene flux shape evolutionary patterns of variation in Drosophila subobscura.
Article in Heredity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Temporal and habitat adaptations in Drosophila subobscura populations: changes in chromosomal inversions.Genetica · 2025Article
- Long-Term Maintenance of Complex Chromosomal Inversion Polymorphism inEcology and evolution · 2024Article
- Article
- Inversion invasions: when the genetic basis of local adaptation is concentrated within inversions in the face of gene flow.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Adaptation of Drosophila subobscura chromosomal inversions to climatic variables: the Balkan natural population of Avala.Genetica · 2021Article
- The Cyclically SeasonalFrontiers in genetics · 2020Article
- Article
- GOOGA: A platform to synthesize mapping experiments and identify genomic structural diversity.PLoS computational biology · 2019Article
- Article
- Patterns of geographic variation of thermal adapted candidate genes in Drosophila subobscura sex chromosome arrangements.BMC evolutionary biology · 2018Article
- Dense gene physical maps of the non-model species Drosophila subobscura.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2017Article
- Predictable phenotypic, but not karyotypic, evolution of populations with contrasting initial history.Scientific reports · 2017Article
- Inversions and adaptation to the plant toxin ouabain shape DNA sequence variation within and between chromosomal inversions of Drosophila subobscura.Scientific reports · 2016Article
- Medium-term changes in Drosophila subobscura chromosomal inversion polymorphism: a possible relation with global warming?Journal of genetics · 2015Article
- Adaptive Role of Inversion Polymorphism of Drosophila subobscura in Lead Stressed Environment.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Gene flow (defined as allele exchange between populations) and gene flux (defined as allele exchange during meiosis in heterokaryotypic females) are important factors decreasing genetic differentiation between populations and inversions. Many chromosomal inversions are under strong selection and their role in recombination reduction enhances the maintenance of their genetic distinctness. Here we analyze levels and patterns of nucleotide diversity, selection and demographic history, using 37 individuals of Drosophila subobscura from Mount Parnes (Greece) and Barcelona (Spain). Our sampling focused on two frequent O-chromosome arrangements that differ by two overlapping inversions (OST and O(3+4)), which are differentially adapted to the environment as observed by their opposing latitudinal clines in inversion frequencies. The six analyzed genes (Pif1A, Abi, Sqd, Yrt, Atpα and Fmr1) were selected for their location across the O-chromosome and their implication in thermal adaptation. Despite the extensive gene flux detected outside the inverted region, significant genetic differentiation between both arrangements was found inside it. However, high levels of gene flow were detected for all six genes when comparing the same arrangement among populations. These results suggest that the adaptive value of inversions is maintained, regardless of the lack of genetic differentiation within arrangements from different populations, and thus favors the Local Adaptation hypothesis over the Coadapted Genome hypothesis as the basis of the selection acting on inversions in these populations.
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