ArticleNeuropharmacology2013
The influence of acute and chronic alcohol consumption on response time distribution in adolescent rhesus macaques.
Article in Neuropharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Sex differences in the prospective association of excessively long reaction times and hazardous cannabis use at six months.Addictive behaviors reports · 2024Article
- Younger, drunk, and fast: Paradoxical rapid reaction time in hazardous drinkers.Journal of psychopharmacology (Oxford, England) · 2023Article
- Mapping nonlinear receptive field structure in primate retina at single cone resolution.eLife · 2015Article
- Chronic periadolescent alcohol consumption produces persistent cognitive deficits in rhesus macaques.Neuropharmacology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAnalysis of the distribution of reaction times (RTs) in behavioral tasks can illustrate differences attributable to changes in attention, even when no change in mean RT is observed. Detrimental attentional effects of both acute and chronic exposure to alcohol may therefore be revealed by fitting RT data to an ex-Gaussian probability density function which identifies the proportion of long-RT responses.
methodsAdolescent male rhesus macaques completed a 5-choice serial reaction time task (5CSRT) after acute alcohol consumption (up to 0.0, 1.0 and 1.5 g/kg). Monkeys were next divided into chronic alcohol (N = 5) and control groups (N = 5); the experimental group consumed 1.5-3.0 g/kg alcohol for 200 drinking sessions. Unintoxicated performance in the 5CSRT task was determined systematically across the study period and the effect of acute alcohol was redetermined after the 180th drinking session. The effect of extended abstinence from chronic alcohol was determined across 90 days.
resultsAcute alcohol exposure dose-dependently reduced the probability of longer RT responses without changing the mean or the standard deviation of the RT distribution. The RT distribution of control monkeys tightened across 10 months whereas that of the chronic alcohol group was unchanged. Discontinuation from chronic alcohol increased the probability of long RT responses with a difference from control animals observed after 30 days of discontinuation.
conclusionsAlcohol consumption selectively affected attention as reflected in the probability of long RT responses. Acute alcohol consumption focused attention, chronic alcohol consumption impaired the maturation of attention across the study period and alcohol discontinuation impaired attention.
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