ArticleEuropean journal of human genetics : EJHG2013
Mosaic copy number variation in schizophrenia.
Article in European journal of human genetics : EJHG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- ARFID Genes and Environment (ARFID-GEN): study protocol.BMC psychiatry · 2023Article
- Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrentCell genomics · 2023Article
- Analysis of Copy Number Variation of DNA Repair/Damage Response Genes in Tumor Tissues.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A genetic risk score using human chromosomal-scale length variation can predict schizophrenia.Scientific reports · 2021Article
- Somatic copy number variants in neuropsychiatric disorders.Current opinion in genetics & development · 2021Review
- Somatic mosaicism and neurodevelopmental disease.Nature neuroscience · 2018Review
- Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity.BMC genetics · 2016Article
- Transcriptomics analysis of iPSC-derived neurons and modeling of neuropsychiatric disorders.Molecular and cellular neurosciences · 2016Review
- Animal models of gene-environment interaction in schizophrenia: A dimensional perspective.Progress in neurobiology · 2016Review
- Allele-specific copy-number discovery from whole-genome and whole-exome sequencing.Nucleic acids research · 2015Article
- Copy number variation in schizophrenia in Sweden.Molecular psychiatry · 2014Article
- Jumping on the Train of Personalized Medicine: A Primer for Non-Geneticist Clinicians: Part 2. Fundamental Concepts in Genetic Epidemiology.Current psychiatry reviews · 2014Article
- Computational methods for detecting copy number variations in cancer genome using next generation sequencing: principles and challenges.Oncotarget · 2013Review
Corrections and comments
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Authors and funding
21 authors at 13 institutions in 6 countries.
Funding
Abstract
Recent reports suggest that somatic structural changes occur in the human genome, but how these genomic alterations might contribute to disease is unknown. Using samples collected as part of the International Schizophrenia Consortium (schizophrenia, n=3518; control, n=4238) recruited across multiple university research centers, we assessed single-nucleotide polymorphism genotyping arrays for evidence of chromosomal anomalies. Data from genotyping arrays on each individual were processed using Birdsuite and analyzed with PLINK. We validated potential chromosomal anomalies using custom nanostring probes and quantitative PCR. We estimate chromosomal alterations in the schizophrenia population to be 0.42%, which is not significantly different from controls (0.26%). We identified and validated a set of four extremely large (>10 Mb) chromosomal anomalies in subjects with schizophrenia, including a chromosome 8 trisomy and deletion of the q arm of chromosome 7. These data demonstrate that chromosomal anomalies are present at low frequency in blood cells of both control and schizophrenia subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.