ArticleAmerican journal of physiology. Endocrinology and metabolism2013
Mechanisms by which the orexigen NPY regulates anorexigenic α-MSH and TRH.
Article in American journal of physiology. Endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Thyroid Response to Peripheral Endocrine Factors: Neuropeptide Y Influences Thyroid Function in the ReptileInternational journal of molecular sciences · 2025Article
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- A Comparison of Gene Expression Profiles of Rat Tissues after Mild and Short-Term Calorie Restrictions.Nutrients · 2021Article
- Review
- Contribution of Baroreflex Afferent Pathway to NPY-Mediated Regulation of Blood Pressure in Rats.Neuroscience bulletin · 2020Article
- Fasting induces remodeling of the orexigenic projections from the arcuate nucleus to the hypothalamic paraventricular nucleus, in a growth hormone secretagogue receptor-dependent manner.Molecular metabolism · 2020Article
- Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss.Scientific reports · 2019Article
- Hypothalamic Mitochondrial Dysfunction as a Target in Obesity and Metabolic Disease.Frontiers in endocrinology · 2018Review
- Exchange factors directly activated by cAMP mediate melanocortin 4 receptor-induced gene expression.Scientific reports · 2016Article
- Genomic Effect of Triclosan on the Fetal Hypothalamus: Evidence for Altered Neuropeptide Regulation.Endocrinology · 2016Article
- Glucose Enhances Basal or Melanocortin-Induced cAMP-Response Element Activity in Hypothalamic Cells.Molecular endocrinology (Baltimore, Md.) · 2016Article
- The Nutrient and Energy Sensor Sirt1 Regulates the Hypothalamic-Pituitary-Adrenal (HPA) Axis by Altering the Production of the Prohormone Convertase 2 (PC2) Essential in the Maturation of Corticotropin-releasing Hormone (CRH) from Its Prohormone in Male Rats.The Journal of biological chemistry · 2016Article
- Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Central Sirt1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced obese male rats.Endocrinology · 2015Article
- Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction.Frontiers in aging neuroscience · 2015Review
- Minireview: Central Sirt1 regulates energy balance via the melanocortin system and alternate pathways.Molecular endocrinology (Baltimore, Md.) · 2014Review
- Central Sirt1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced obese male rats.Endocrinology · 2014Article
- Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Protein posttranslational processing is a cellular mechanism fundamental to the generation of bioactive peptides, including the anorectic α-melanocyte-stimulating hormone (α-MSH) and thyrotropin-releasing hormone (TRH) peptides produced in the hypothalamic arcuate (ARC) and paraventricular (PVN) nuclei, respectively. Neuropeptide Y (NPY) promotes positive energy balance in part by suppressing α-MSH and TRH. The mechanism by which NPY regulates α-MSH output, however, is not well understood. Our results reveal that NPY inhibited the posttranslational processing of α-MSH's inactive precursor proopiomelanocortin (POMC) by decreasing the prohormone convertase-2 (PC2). We also found that early growth response protein-1 (Egr-1) and NPY-Y1 receptors mediated the NPY-induced decrease in PC2. NPY given intra-PVN also decreased PC2 in PVN samples, suggesting a reduction in PC2-mediated pro-TRH processing. In addition, NPY attenuated the α-MSH-induced increase in TRH production by two mechanisms. First, NPY decreased α-MSH-induced CREB phosphorylation, which normally enhances TRH transcription. Second, NPY decreased the amount of α-MSH in the PVN. Collectively, these results underscore the significance of the interaction between NPY and α-MSH in the central regulation of energy balance and indicate that posttranslational processing is a mechanism that plays a specific role in this interaction.
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