ArticleAmerican journal of physiology. Endocrinology and metabolism2013
Differential responses of pancreatic β-cells to ROS and RNS.
Article in American journal of physiology. Endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
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- 'Oxidative stress'-A new target in the management of diabetes mellitus.Journal of family medicine and primary care · 2023Review
- Cytokine and Nitric Oxide-Dependent Gene Regulation in Islet Endocrine and Nonendocrine Cells.Function (Oxford, England) · 2022Article
- The Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling.Oxidative medicine and cellular longevity · 2022Review
- Single-cell RNA sequencing of mouse islets exposed to proinflammatory cytokines.Life science alliance · 2021Article
- Inhibition of oxidative metabolism by nitric oxide restricts EMCV replication selectively in pancreatic beta-cells.The Journal of biological chemistry · 2020Article
- Inhibition of mitochondrial oxidative metabolism attenuates EMCV replication and protects β-cells from virally mediated lysis.The Journal of biological chemistry · 2020Article
- Can insulin secreting pancreatic β-cells provide novel insights into the metabolic regulation of the DNA damage response?Biochemical pharmacology · 2020Review
- The Role of MicroRNAs in Diabetes-Related Oxidative Stress.International journal of molecular sciences · 2019Review
- Pancreatic β-cells detoxify HThe Journal of biological chemistry · 2019Article
- Braving the Element: Pancreatic β-Cell Dysfunction and Adaptation in Response to Arsenic Exposure.Frontiers in endocrinology · 2019Review
- Dual Role of Nitric Oxide in Regulating the Response of β Cells to DNA Damage.Antioxidants & redox signaling · 2018Review
- Article
- Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes.Frontiers in physiology · 2018Review
- Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response.Molecular and cellular biology · 2016Article
- Effect of Hypertriglyceridemia on Beta Cell Mass and Function in ApoC3 Transgenic Mice.The Journal of biological chemistry · 2016Article
- FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice.Endocrinology · 2016Article
- Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes.Diabetes · 2015Article
- Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells.Pflugers Archiv : European journal of physiology · 2015Article
- How the location of superoxide generation influences the β-cell response to nitric oxide.The Journal of biological chemistry · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) direct the activation of distinct signaling pathways that determine cell fate. In this study, the pathways activated and the mechanisms by which ROS and RNS control the viability of pancreatic β-cells were examined. Although both nitric oxide and hydrogen peroxide (H₂O₂) induce DNA damage, reduce cell viability, and activate AMPK, the mechanisms of AMPK activation and cell death induction differ between each reactive species. Nitric oxide activates the unfolded protein and heat shock responses and MAPK kinase signaling, whereas H₂O₂ stimulates p53 stabilization and poly(ADP-ribose) polymerase (PARP) activation but fails to induce the unfolded protein or heat shock responses or MAPK activation. The control of cell fate decisions is selective for the form of stress. H₂O₂-mediated reduction in β-cell viability is controlled by PARP, whereas cell death in response to nitric oxide is PARP independent but associated with the nuclear localization of GAPDH. These findings show that both ROS and RNS activate AMPK, induce DNA damage, and reduce cell viability; however, the pathways controlling the responses of β-cells are selective for the type of reactive species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.