ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2013
Myocardial perfusion imaging with a solid-state camera: simulation of a very low dose imaging protocol.
Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 108 citations in OpenAlex.
- Dose reduction in half-time myocardial perfusion SPECT-CT with multifocal collimation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Trial
- Development and validation of a patient-tailored dose regime in myocardial perfusion imaging using conventional SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Trial
- Development and validation of a patient-tailored dose regime in myocardial perfusion imaging using CZT-SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Trial
- A Clinical Impact Study of Myocardial Perfusion Imaging Comparing Three Different Cardiac Software Packages at 1-Year Follow-Up.World journal of nuclear medicine · 2026Article
- Comparison of 2D-QCA, 3D-QCA and coronary angiography derived FFR in predicting myocardial ischemia assessed by CZT-SPECT MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Deep learning-based denoising in projection-domain and reconstruction-domain for low-dose myocardial perfusion SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Personalization ofEJNMMI physics · 2023Article
- Technical note: Partitioning of gated single photon emission computed tomography raw data for protocols optimization.Journal of applied clinical medical physics · 2022Article
- Optimal Protocol of Myocardial Perfusion Imaging for Reduction of Radiation Exposure.Annals of nuclear cardiology · 2022Review
- Do we need dedicated cardiac SPECT systems?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Research Progress of Imaging Methods for Detection of Microvascular Angina Pectoris in Diabetic Patients.Frontiers in cardiovascular medicine · 2021Review
- Hybrid solid-state SPECT/CT left atrial innervation imaging for identification of left atrial ganglionated plexi: Technique and validation in patients with atrial fibrillation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Effect of reduced photon count levels and choice of normal data on semi-automated image assessment in cardiac SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Effect of reduced photon count levels and choice of normal data on semi-automated image assessment in cardiac SPECT: Doing more with fewer counts.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Review
- EANM procedural guidelines for myocardial perfusion scintigraphy using cardiac-centered gamma cameras.European journal of hybrid imaging · 2019Article
- Impact of non-specific normal databases on perfusion quantification of low-dose myocardial SPECT studies.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Minimal rest activity for SPECT myocardial perfusion imaging in a one-day stress-first protocol.European journal of nuclear medicine and molecular imaging · 2019Article
- Automatic evaluation of myocardial perfusion on SPECT: Need for "Normality".Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledHigh-sensitivity dedicated cardiac camera systems provide an opportunity to lower the injected doses for SPECT myocardial perfusion imaging (MPI), but the exact limits for lowering doses have not been determined. List-mode data acquisition allows for reconstruction of various fractions of acquired counts, enabling a simulation of gradually lower administered dose. We aimed to determine the feasibility of very low dose MPI by exploring the minimal count level in the myocardium required for accurate MPI.
methodsSeventy-nine patients were studied (mean body mass index, 30.0 ± 6.6; range, 20.2-54.0 kg/m(2)) who underwent 1-d standard-dose (99m)Tc-sestamibi exercise or adenosine rest-stress MPI for clinical indications using a cadmium-zinc-telluride dedicated cardiac camera. The imaging time was 14 min, with averaged 803 ± 200 MBq (21.7 ± 5.4 mCi) of (99m)Tc injected at stress. To simulate clinical scans with a lower dose at that imaging time we reframed the list-mode raw data. Accordingly, 6 stress-equivalent datasets were reconstructed containing various count fractions of the original scan. Automated quantitative perfusion and gated SPECT software was used to quantify total perfusion deficit (TPD) and ejection fraction for all 553 datasets (7 × 79). The minimal acceptable left ventricular region counts were determined on the basis of a previous report with repeatability of same-day, same-injection Anger camera studies. Pearson correlation coefficients and the SD of differences in TPD for all scans were calculated.
resultsThe correlations of quantitative perfusion and function analysis were excellent for both global and regional analysis between original scans and all simulated low-count scans (all r ≥ 0.95, P < 0.0001). The minimal acceptable counts were determined to be 1.0 million for the left ventricular region. At this count level, the SD of differences was 1.7% for TPD and 4.2% for ejection fraction. This count level would correspond to a 92.5-MBq (2.5-mCi) injected dose for the 14-min acquisition or 125.8-MBq (3.4-mCi) injected dose for the 10-min acquisition.
conclusion1.0 million counts appear to be sufficient to produce myocardial images that agree well with 8.0-million-count images on quantitative perfusion and function parameters. With a dedicated cardiac camera, these images can be obtained over 10 min with an effective radiation dose of less than 1 mSv without significant sacrifice of accuracy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.