ArticlePlant physiology2013
The Arabidopsis TUMOR PRONE5 gene encodes an acetylornithine aminotransferase required for arginine biosynthesis and root meristem maintenance in blue light.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 38 citations in OpenAlex.
- Arginine, a key amino acid for nitrogen nutrition and metabolism of forest trees.Journal of experimental botany · 2025Review
- Mapping multi-substrate specificity of Arabidopsis aminotransferases.Nature plants · 2025Article
- Amino acids biosynthesis in root hair development: a mini-review.Biochemical Society transactions · 2024Review
- Whole-Genome Sequencing and Analysis of Tumour-Forming Radish (International journal of molecular sciences · 2024Article
- Nutrient Solution Flowing Environment Affects Metabolite Synthesis Inducing Root Thigmomorphogenesis of Lettuce (International journal of molecular sciences · 2023Article
- Metabolomics Combined with Transcriptomics Analysis Revealed the Amino Acids, Phenolic Acids, and Flavonol Derivatives Biosynthesis Network in DevelopingFoods (Basel, Switzerland) · 2022Article
- Enzymes Involved in the Biosynthesis of Arginine from Ornithine in Maritime Pine (Plants (Basel, Switzerland) · 2020Article
- Plant tumors: a hundred years of study.Planta · 2020Review
- Functional Relevance of Citrulline in the Vegetative Tissues of Watermelon During Abiotic Stresses.Frontiers in plant science · 2020Article
- Biological Roles of Ornithine Aminotransferase (OAT) in Plant Stress Tolerance: Present Progress and Future Perspectives.International journal of molecular sciences · 2018Review
- Group-wise ANOVA simultaneous component analysis for designedMetabolomics : Official journal of the Metabolomic Society · 2018Article
- Article
- Physiological implications of arginine metabolism in plants.Frontiers in plant science · 2015Review
- Transcriptome profiling shows gene regulation patterns in a flavonoid pathway in response to exogenous phenylalanine in Boesenbergia rotunda cell culture.BMC genomics · 2014Article
- An appropriate concentration of arginine is required for normal root growth in rice.Plant signaling & behavior · 2014Article
- De novo comparative transcriptome analysis of Acremonium chrysogenum: high-yield and wild-type strains of cephalosporin C producer.PloS one · 2014Article
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4 authors at 1 institution in 1 country.
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Abstract
Arginine is an essential amino acid necessary for protein synthesis and is also a nitrogen storage compound. The genes encoding the enzymes of arginine biosynthesis in plants are not well characterized and have mainly been predicted from homologies to bacterial and fungal genes. We report the cloning and characterization of the TUMOR PRONE5 (TUP5) gene of Arabidopsis (Arabidopsis thaliana) encoding an acetylornithine aminotransferase (ACOAT), catalyzing the fourth step of arginine biosynthesis. The free arginine content was strongly reduced in the chemically induced recessive mutant tup5-1, root growth was restored by supplementation with arginine and its metabolic precursors, and a yeast (Saccharomyces cerevisiae) ACOAT mutant was complemented by TUP5. Two null alleles of TUP5 caused a reduced viability of gametes and embryo lethality, possibly caused by insufficient Arg supply from maternal tissue. TUP5 expression is positively regulated by light, and a TUP5-green fluorescent protein was localized in chloroplasts. tup5-1 has a unique light-dependent short root phenotype. Roots of light-grown tup5-1 seedlings switch from indeterminate growth to determinate growth with arresting cell production and an exhausted root apical meristem. The inhibitory activity was specific for blue light, and the inhibiting light was perceived by the root. Thus, tup5-1 reveals a novel role of amino acids and blue light in regulating root meristem function.
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